Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

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Recent Submissions

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Prevalence of Ideation, Attempt and Completed Suicide in Iranian Substance Abusers: A Scoping Review and Meta-Analysis
(Brieflands, 2024-12-31) Fatemeh Hamedi; Zahra Mirzaee; Hamideh Ghasemi; Fatemeh Zahra Rasoulinejad; Asieh Slmannejad; Mohsen Salmannejad; Mahkameh Shakouri
Context: Suicide is a serious public health issue that is more prevalent among substance abusers. Objectives: This scoping review aims to examine the prevalence of suicide attempts and completed suicides in this target population. Data Sources: A systematic search was conducted without language or time restrictions in electronic databases including PubMed, Scopus, and Web of Sciences and Google Scholar using medical subject headings (MeSH) keywords. The primary outcome was the overall prevalence of suicide, while secondary outcomes included the prevalence of suicide attempts, suicidal ideation, and completed suicides among the target population. Study Selection: All observational studies (including cohort, case-control, and cross-sectional studies) were included. Two independent reviewers performed the selection of relevant studies throughout all stages of the study selection process, including screening, full-text review, and quality assessment using a modified version of the Department of Health & Human Services tool. Data Extraction: Data extraction was carried out using Excel, and data analysis was performed using Stata version 17. Ultimately, 13 studies were included in the systematic review and meta-analysis process. Results: The findings revealed that personal and family history of suicide attempts, as well as psychological disorders, significantly increased the odds of mortality. Furthermore, the synthesis of studies indicated that the overall prevalence of suicide (including completed suicides, suicidal ideation, and suicide attempts) among this population was: ES [95% confidence interval] = 0.42 [0.31 to 0.52]. In the subgroup analysis, the results showed: The prevalence of completed suicides: ES [95% confidence interval] = 0.59 [0.52 to 0.66]. The prevalence of suicidal ideation: ES [95% confidence interval] = 0.29 [0.26 to 0.31]. The prevalence of suicide attempts: ES [95% confidence interval] = 0.29 [-0.17 to 0.76]. Conclusions: The results of this study demonstrate a high prevalence of both completed suicides and suicide attempts among individuals with substance abuse issues. To reduce the incidence of these behaviors, governments should design programs aimed at decreasing the rates of Poisoning and mortality in this population.
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Investigating the Duties and Performance of Advisors from the Perspective of Students at Shahroud University of Medical Sciences
(Brieflands, 2025-03-31) Omid Garkaz; Sahar Paryab; Marjan Dashtipour; Nima Jahan; Seyed Amirhossein Taghavi; Farideh Dasturani; Omid Garkaz [0000-0002-7192-8629]
Background: Providing guidance and counseling services by advisors provides students with appropriate solutions to solve problems, which increases insight, growth of social relationships, and greater efficiency of the educational and training system. Objectives: This study was conducted to investigate the duties and performance of advisors from the perspective of students at Shahroud University of Medical Sciences. Methods: This descriptive-analytical study was conducted using a stratified random sampling method on 336 students of Shahroud University of Medical Sciences in the academic year 2023 - 2024. To collect data, a demographic information checklist and a questionnaire on the duties and performance of consulting professors by Ebrahimi Pour et al. were used. After collection, the data were entered into SPSS18 and analyzed using descriptive and analytical statistics. Results: In this study, a total of 336 people participated in the study, with the average age of the participants being 21.25 ± 1.70 years, most of the participants were female (59.8%), 201 were in the 18 - 21 age group (61%), 311 were single, 116 were in the medical field (34.5%), 122 were in the medical school (36.3%), 211 were in the undergraduate level (62.8%), 300 were in the full-time program (89.3%), 255 were non-native (75.9%), and the duration of counseling was between 0-12 months (87.5%). And except for age group and tasks (0.288), faculty and performance (0.027), section and performance (0.317), and the duration of counseling and tasks (0.071), there was no significant relationship, and there was a significant relationship between the other variables and the mean, standard deviation of the task score 73.27 ± 15.92 and the lowest score was 20 and the highest score was 100. In the case of performance, it was 27.38 ± 7.91 and the lowest score was 14 and the highest was 42. Conclusions: Although most students were satisfied with the duties and performance of the advisors, it is still necessary to achieve the desired goals and maintain the conditions, and to provide various facilities to provide better advisory services.
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Down-Regulation of HOTAIR, SUZ12, and DNMT3A by Curcumin Nanoparticles in Glioblastoma
(Brieflands, 2025-05-31) Hassan Maghsoudi; Nahid Pourreza; Maryam Naderi Soorki; Mohammadreza Hajjari; Hassan Maghsoudi [0009-0009-9763-5507]; Nahid Pourreza [0000-0003-0185-1088]; Maryam Naderi Soorki [0000-0003-1477-013X]; Mohammadreza Hajjari [0000-0003-3838-0259]
Background: Despite advances in medical science in the field of cancer, the treatment of glioblastoma (GBM) remains a significant challenge due to its high degree of penetration and the formation of resistant cells. Among the effective herbal compounds in cancer treatment, curcumin is known to be one of the most effective. Curcumin has the potential to modulate critical pathways involved in glioblastoma cell proliferation, apoptosis, cell cycle arrest, oxidative stress, and epigenetic processes. Objectives: In this research, we investigated the effects of curcumin nanoparticles (curcumin-NPs) on the expression of DNMT3A, SUZ12, HOTAIR genes, and MecP2 as important epigenetic factors in a glioblastoma cell line. Methods: Curcumin NPs were synthesized using ultrasonic methods, and their toxic effects on the glioblastoma 1321N1 cell line were measured 48 hours after treatment using the MTT assay. RT-qPCR and Western blot were used to measure the expression levels of different epigenetic factors, including DNMT3A, SUZ12, HOTAIR genes, and MecP2 protein. Results: The results showed a 50% inhibitory effect at the IC50 concentration (1.7μM) of curcumin-NPs prepared by ultrasonic method on a glioblastoma cell line. The NPs can reduce the invasion, growth, and migration of cancer cells. Also, a significant decrease was found in the expression levels of SUZ12, HOTAIR, DNMT3A, and MecP2 protein at the IC50 concentration of curcumin-NPs, which is statistically significant (mean ± SD, n = 2, P < 0.05). Conclusions: Our study demonstrated that curcumin-NPs can affect the viability and proliferation of the glioblastoma cell line by mediating the level of some essential epigenetic regulators.
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Apoptotic Effects of Steviol Glycoside on MCF-7 and A2780 Cell Lines in Breast and Ovarian Cancer
(Brieflands, 2025-05-31) Hasan Jasim Hami; Mehdi Haghi; Mohammad Ali Hoseinpour Feizi; Hasan Jasim Hami [0009-0003-0336-1039]; Mehdi Haghi [0000-0001-8400-4209]; Mohammad Ali Hoseinpour Feizi [0000-0002-1508-5022]
Background: Breast and ovarian cancers are prevalent among women, prompting researchers to focus on developing new pharmaceutical agents and innovative drug delivery systems aimed at enhancing treatment efficacy while minimizing side effects. Steviol glycosides offer a promising approach to cancer treatment due to their broad anticancer activity, low toxicity, selective targeting of cancer cells, and potential to enhance chemotherapy efficacy. Objectives: This study explores the potential of steviol glycoside, a natural compound derived from the Stevia rebaudiana plant, as an anticancer agent targeting breast (MCF-7) and ovarian (A2780) cancer cell lines. Methods: MCF-7 and A2780 cells were cultured under standard conditions and treated with varying concentrations of steviol glycoside (0, 10, 20, 30, 40, and 50 µM) over different time points (24, 48, and 72 hours). Cell viability was assessed using the MTT assay, and the expression of apoptotic and anti-apoptotic genes was evaluated. Statistical analyses were performed using a t-test, with P-values calculated based on a significance threshold of 0.05. Graphs were generated using GraphPad Prism software. Results: The inhibitory concentration 50% (IC50) values for MCF-7 cells were 30 μM, 24 μM, and 22 μM at 24, 48, and 72 hours, respectively. For A2780 cells, the corresponding IC50 values were 24 μM, 20 μM, and 19 μM at the same time points. The fold change in Bax and Bad gene expression increased with rising concentrations of steviol glycoside. At concentrations above 20 μM, this increase became statistically significant (P < 0.001). Conversely, Bcl-2 gene expression exhibited a statistically significant decrease (P < 0.001) at these concentrations. Conclusions: The findings highlight the therapeutic potential of steviol glycoside in treating breast and ovarian cancers, emphasizing the need for deeper investigation into its molecular pathways to fully understand its mechanisms. Despite its promise, significant challenges exist in translating laboratory results into clinical applications. Key obstacles include establishing appropriate dosing, assessing interactions with other medications, and conducting comprehensive trials to ensure safety and efficacy. Acknowledging these limitations enhances transparency and underscores the necessity for additional research to progress toward human trials.
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Haloxylon ammodendron: Assessing Antioxidant and Antimicrobial Efficacy with Minimum Inhibitory Concentration (MIC) Determination in Bacterial Strains
(Brieflands, 2025-05-31) Marzieh Heydarpour Ahvazi; Zeinab Zaheri Abdevand; Fereshteh Golfakhrabadi; Zahra Farshadzadeh; Saina Najafi; Mehdi Fazeli; Zeinab Zaheri Abdevand [0000-0003-0874-1260]; Fereshteh Golfakhrabadi [0000-0002-0606-2937]; Zahra Farshadzadeh [0000-0001-6461-4376]
Background: Haloxylon ammodendron belongs to the genus Haloxylon of the Amaranthaceae family. This study is the first to assess the antibacterial and antifungal properties of H. ammodendron ethanolic extract and provides an analysis of the plant’s antioxidant capacity. Additionally, the research offers insights into the phenolic content of the plant’s ethanolic extract, which is directly linked to its bioactivity. Objectives: The study aimed to evaluate the antioxidant, antibacterial, and antifungal activity and determine the phenolic content of H. ammodendron ethanolic extract. Methods: The maceration method was used to prepare H. ammodendron ethanolic extract. The antibacterial and antifungal activity of this extract was investigated using two strains of gram-positive bacteria (Staphylococcus aureus, Streptococcus mutans), four strains of gram-negative bacteria (Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli), and one fungal strain (Candida albicans). The agar well diffusion method was used to evaluate the inhibition of bacterial growth. The phenolic compounds of H. ammodendron were measured by the Folin-Ciocalteu method. Antioxidant activity was determined by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. Results: The results demonstrated that various concentrations of H. ammodendron ethanolic extract exhibit antibacterial effects. The extract showed the most significant inhibitory effect against S. mutans and S. aureus. The lowest inhibitory effect was observed against A. baumannii and E. coli. This plant showed a significant antioxidant effect (IC50: 0.2 mg/mL). Conclusions: In this study, the H. ammodendron species was investigated for the first time. The results showed that the ethanolic extract of H. ammodendron has an excellent inhibitory effect on gram-positive bacteria. Considering the significant antioxidant effect of this plant, further studies are suggested to explore its therapeutic effects on disorders related to oxidative stress.