Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

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Recent Submissions

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Molecular Docking of Silymarin as a Ligand for Aromatase Enzyme and HIV-1 Reverse Transcriptase Using Molegro Virtual Docker
(Brieflands, 2025-06-30) Ahmad Hafezi; Zahra Khamar; Ahmad Hafezi [0009-0007-8833-8936]; Zahra Khamar [0000-0003-1064-7716]
Background: Molegro Virtual Docker (MVD) software is specifically designed for executing the molecular docking process. It has gained recognition among docking software for its user-friendliness, affordability, and quick result evaluation. The docking procedure can utilize multiple algorithms, and different molecules can be treated as ligands and receptors. Selin marine is one compound that, owing to its appropriate structure, can significantly function as a ligand and inhibitor for key enzymes involved in pathogenesis. Objectives: The primary objective of this research is to perform in silico analyses to explore the potential of silibinin, silidianin, and silychristin molecules as ligands for interaction with the active sites of the Aromatase enzyme and human immunodeficiency virus-1 (HIV-1) reverse transcriptase enzymes. Methods: In this research, the ligand structures were initially obtained from the PubChem database, while the enzyme structures were sourced from the PDB database. Subsequently, the docking process was conducted using the MVD software. Any structural errors in the molecules were rectified utilizing the 'if missing' approach. The cavities associated with the active sites of each enzyme were identified based on the positioning of the primary ligand. To ensure the docking process was executed with maximum precision, the MolDock Score (GRID) and the MolDock simplex evolution (SE) algorithm were employed in the settings, with ten runs conducted for each molecule. Results: The findings from the docking process revealed that the molecules silibinin, silidianin, and silychristin can occupy the active site of the aromatase enzyme, exhibiting free energies of -141.972, -127.805, and -148.425 kcal/mol, respectively. Their ability to form steric interactions and hydrogen bonds suggests that they could serve as effective ligands for interaction with this active site. Furthermore, these ligands exhibit significant potential for establishing hydrogen and ester bonds within the active site of HIV-1 reverse transcriptase, with calculated free energies of -140.701, -138.956, and -135.365 kcal/mol for silibinin, silidianin, and silychristin, respectively. Conclusions: Silymarin demonstrated the ability to interact with the active site of the aromatase enzyme and HIV-1 reverse transcriptase, potentially competing with their primary ligands for binding at this location, thereby inhibiting the activity of both enzymes in affected cells.
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Stage Diagnosis of Hepatitis B Cirrhosis Based on Noninvasive Eye Examination
(Brieflands, 2025-12-31) Tian Fu; Yonggen Xu; Yonggen Xu [0000-0002-9411-4759]
Background: The liver is an important organ of the human body and has the greatest ability to eliminate harmful toxins. Objectives: Hepatitis B cirrhosis is a progressive and life-threatening liver disease, and accurate stage diagnosis is crucial for treatment planning and prognosis prediction. Traditional diagnostic methods for cirrhosis staging often involve invasive procedures or rely on a combination of serological and imaging tests with certain limitations. The main objectives of this study were to comprehensively evaluate the blood flow characteristics in the fundus and to explore the potential of quantifying the stage diagnosis of hepatitis B cirrhosis through non-invasive ophthalmic measurements. By analyzing the blood flow parameters in the retina and choroid, we aimed to establish a new, non-invasive, and convenient method for assessing the severity of hepatitis B cirrhosis. Methods: A total of 20 myopic subjects (40 eyes) were prospectively recruited for this study. All participants provided informed consent, and the study protocol adhered to the tenets of the Declaration of Helsinki. Subjects with other significant systemic diseases (such as diabetes, hypertension with severe complications) or eye diseases that could affect fundus blood flow were excluded. Optical coherence tomography angiography (OCTA) was used as the primary measurement tool. This advanced imaging technique allows for high-resolution, non-invasive visualization of the microvasculature in the eye. The retinal no blood flow zone (FAZ) area was carefully measured, which reflects the integrity and function of the inner retinal capillary network. Additionally, the area of the flow-free perfusion area in the retina was quantified. This parameter can indicate potential ischemic changes in the retinal tissue. Furthermore, the mean choroidal capillary density was measured. The choroid, a vascular layer beneath the retina, plays a crucial role in supplying nutrients and oxygen to the outer retina and photoreceptor cells. Measuring its capillary density can provide valuable information about the overall blood flow status in the posterior segment of the eye. Results: The results demonstrated significant differences in fundus blood flow at almost all levels of the retina and choroid among different stages of hepatitis B cirrhosis. In the superficial retina, there were notable variations in capillary density and perfusion patterns, with more pronounced alterations observed in the advanced stages of cirrhosis. The middle retinal layers also showed distinct changes in blood flow parameters, which correlated well with the progression of liver disease. In the choroid, the mean capillary density decreased gradually as the stage of cirrhosis advanced, indicating compromised blood supply to this important vascular layer. Interestingly, except for the FAZ area in the deep retina, where the statistical significance was on the verge of significance (P = 0.061), all other measured parameters showed significant differences (P < 0.05). The lack of a more significant difference in the deep retinal FAZ area might be due to the relatively stable anatomical structure of this region or the limited sample size of the study, which requires further investigation. Conclusions: Our study clearly showed that fundus blood flow is closely related to the stage diagnosis of hepatitis B cirrhosis. These findings suggest a potential link between the microvascular changes in the eye and the systemic pathophysiological processes occurring in hepatitis B-related liver cirrhosis. Given the non-invasive nature of OCTA and the convenience of eye examinations, we speculated that non-invasive eye examination can be used as a supplementary method for the stage diagnosis of hepatitis B cirrhosis. However, further large-scale, multi-center studies are needed to validate these findings and establish standardized diagnostic criteria based on fundus blood flow parameters for hepatitis B cirrhosis staging.
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Assessing Awareness, Attitudes, and Practices of Medical Students Regarding Food Hygiene and Safety: A Cross-sectional Study at Zahedan University of Medical Sciences
(Brieflands, 2025-07-31) Alireza Pourali; Mahdiye Shahbazi; Narjes Sargolzaei; Khashayar Sarabandi; Maryam Beigomi; Mohammad Reza Shadan; Alireza Pourali [0009-0008-1076-2929]; Narjes Sargolzaei [0000-0002-7869-1564]
Background: Given the importance of health behaviors among young people and students, who serve as role models for other societal segments, understanding their awareness and attitudes can significantly influence public health focus. Assessing students' awareness and related factors regarding food hygiene is crucial. Objectives: This study aims to investigate the awareness, attitude, and performance of medical students at Zahedan University of Medical Sciences concerning health and food safety. Methods: This study involved 140 medical students from Zahedan University of Medical Sciences, selected through convenience sampling. Data were collected using a questionnaire and analyzed using SPSS software version 22, employing independent t-tests and analysis of variance (ANOVA). Results: The study found that the average scores for awareness, attitude, and performance of medical students in the field of health and food safety were 25.05 (moderate awareness), 34.45 (poor attitude), and 25.52 (moderate performance), respectively. The students' attitude level was lower than their awareness and performance levels. There was a significant relationship between the level of awareness and educational level (P = 0.006), the level of attitude and educational level (P = 0.041), and the level of attitude and age (P = 0.015). Conclusions: This study revealed that despite a relatively high level of awareness regarding food hygiene and safety among students, a change in attitude did not necessarily translate into a change in practice.
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The Effect of Branched-Chain Amino Acids (L-Valine, L-Leucine and L-Isoleucine) on Intestinal Morphology and IGF-1 Gene Expression in Broiler Chickens
(Brieflands, 2025-04-30) Shahriyar Khalilzadeh; Abolfazl Zarei; Nima Eila
Background: Insulin-like growth factor 1 (IGF-1) is an important regulator of growth, amino acid (AA) elongation, glucose metabolism, DNA synthesis, protein synthesis, and the proliferation and differentiation of various cell types. Therefore, IGF-1 may affect intestinal morphology by increasing nutrient uptake into intestinal enterocytes and promoting cell proliferation. Objectives: The present study aimed to evaluate the effects of different levels of branched-chain amino acids (BCAAs) (L-valine, L-leucine, and L-isoleucine) in low crude protein (CP) diets on intestinal morphology and IGF-1 gene expression in broiler chickens. Methods: A total of 480 one-day-old male and female broilers of the Ross 308 strain, with an average weight of 42.75 ± 0.47 g, were used. This experiment was carried out as a 3 × 2 factorial in the form of a completely randomized design with 6 treatments and 4 replications. The experimental diets included three levels of BCAA (0%, 10%, and 20% higher than the standard) and two levels of CP (standard or 10% lower than the standard). Results: Using 20% BCAA in the diet increased the villus height to crypt depth (VH/CD) ratio in the duodenum, jejunum, and ileum compared to the standard level of BCAA (P < 0.05). Reducing CP by 10% significantly lowered the VH/CD ratio in the duodenum, jejunum, and ileum (P < 0.05). The expression of IGF-1 mRNA in liver tissue was higher in the groups containing 10% BCAA than in the standard BCAA groups, regardless of the CP level. Conclusions: In general, BCAA supplementation could be beneficial for improving intestinal morphology and IGF-1 gene expression in broiler chickens on low CP diets.
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The Effect of Pulsed Electromagnetic Field Therapy on Fatigue, Depression, and Quality of Life in Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials
(Brieflands, 2025-01-31) Somaieh Ashrafi; Majid Barekatain; Fatemeh Rajabi; Shahrazad Mortazavi; Naghmeh Yazdi; Ali Shariat; Majid Barekatain [0000-0003-4001-6261]; Fatemeh Rajabi [0000-0003-0541-2250]
Background: Multiple sclerosis (MS) is a debilitating neurodegenerative condition characterized by various symptoms, particularly fatigue, which can significantly impact mental health and quality of life. Evidence regarding the efficacy of pulsed electromagnetic field (PEMF) therapy in managing certain symptoms of MS remains controversial. Objectives: This systematic review aimed to evaluate randomized clinical trials (RCTs) assessing the effects of PEMF therapy on fatigue, depression, and quality of life in individuals with MS. Methods: The electronic databases PubMed, Scopus, and Web of Science were searched for articles published between 1990 and 2023 using the keywords magnetic field therapy and MS. Two independent reviewers conducted the processes of screening, data extraction, and quality assessment. Fatigue was analyzed as the primary outcome, while depression and quality of life were considered secondary outcomes. Results: The search yielded 1,768 articles, of which 8 met the inclusion criteria for this review. A total of 372 participants were analyzed, 267 (71.7%) of whom were women. The intervention duration ranged from 3 to 12 weeks. Fatigue levels were reported in all included studies, while depression and quality of life were assessed in three studies. Conclusions: Compared to placebo, beneficial effects of PEMF therapy on fatigue severity were observed in only two studies, while the remaining studies showed no significant differences between groups. Furthermore, quality of life improved in only one study, and depression scores were comparable between groups at the end of all three studies. Additional trials with longer intervention durations, larger sample sizes, advanced technological devices, and objective assessment tools are needed to resolve this controversy.