Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

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The Effects of Benson's Relaxation via Podcast on Stress Levels and Self-efficacy of Infertile Women Referred to the Infertility Clinic of Amir Al-Momenin Hospital (AS) in Zabol
(Brieflands, 2026-04-30) Soleyman Saravani; Khadijeh Saravani; Zahra Shahraki; Zeynab Sharifi
Background and Objectives: This study aimed to evaluate the impact of Benson's relaxation method, delivered via podcasts, on stress reduction and the enhancement of self-efficacy in infertile women. Infertility, which affects 60 to 80 million couples annually worldwide, was addressed through a semi-experimental pre-post design study. Methods: A total of 46 participants completed the Persian versions of the Perceived Stress Scale-10 (PSS-10) and the Infertility Self-efficacy Scale prior to the intervention. Participants practiced Benson's relaxation technique for 15 minutes twice daily over an eight-week period using audio CDs. Data were analyzed using analysis of covariance (ANCOVA) with SPSS-27 software to assess the effectiveness of the intervention. Results: The study included 61 participants aged 18 to 40 years (mean age: 28.67 ± 6.498), and evaluated the effects of relaxation exercises on stress and self-efficacy among infertile women. The average duration of infertility was 4.24 ± 3.95 years. Following the intervention, stress levels significantly decreased (P = 0.000), while self-efficacy levels significantly increased (P = 0.000), indicating the effectiveness of the relaxation exercises. However, no significant relationships were found between age, education, or place of residence and changes in stress or self-efficacy levels (P > 0.05). These findings highlight the overall impact of relaxation techniques, regardless of demographic factors. Conclusions: Benson's relaxation method delivered through podcasts appears to be an effective intervention for reducing stress and increasing self-efficacy in infertile women.
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Association Between Periodontitis and NAFLD-Related Diseases: Results from the NHANES and Mendelian Randomization Study
(Brieflands, 2025-12-31) Xia Yang; Wenhui Wang; Xiaoyu Wang; Shuli Li; Xiaomei Zhao; Honglin Liu; Honglin Liu [0000-0001-8136-4014]
Background and Objectives: The purpose of this research is to utilize a combination of cross-sectional data and Mendelian randomization (MR) to establish a causal association between periodontitis and non-alcoholic fatty liver disease [NAFLD; now also referred to as metabolic associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD)], including the progression of the latter to liver fibrosis. Methods: First, a cross-sectional analysis included 4,425 participants from the National Health and Nutrition Examination Survey (NHANES) 2009 - 2014. The study employed two multivariable logistic regression models to evaluate the correlation between advanced fibrosis (AF) and periodontitis, as well as NAFLD. Model 2 controlled for age, gender, and race, while model 3 was additionally adjusted for Body Mass Index (BMI), education level, household income poverty ratio, smoking status, physical activity, and history of diabetes. Second, in the two-sample MR analysis, periodontitis (n = 17,353 cases) was used as the exposure, and NAFLD (n = 2,275 cases), fibrosis (n = 146 cases), cirrhosis (n = 1,142 cases), and fibrosis/cirrhosis (n = 1,841 cases) were used as outcomes, and causality validation was performed. Sensitivity analyses, such as heterogeneity tests, multiple validity tests, and exclusion analyses, were also conducted to ensure the reliability of the findings. Results: Both the cross-sectional and MR analyses yielded null results. In the observational study, including participants (mean age: 53.1 years, 50.3% male), there was no significant correlation between periodontitis and NAFLD or AF. Similarly, MR analyses found no significant association between genetically predicted periodontitis and liver conditions. Conclusions: According to cross-sectional research, there is no discernible link between NAFLD or liver fibrosis and periodontal disease, and MR analyses do not support a causal relationship between them.
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Upregulation of miRNA 146a in Oral Squamous Cell Carcinoma Compared to Oral Lichen Planus: A Potential Diagnostic Biomarker
(Brieflands, 2026-01-31) Mana Homaie; Maliheh Entezari; Reyhaneh Shoorgashti; Sareh Farhadi; Maliheh Entezari [0000-0003-4191-3351]; Reyhaneh Shoorgashti [0000-0002-1658-8983]; Sareh Farhadi [0000-0003-2202-5797]
Background: Oral lichen planus (OLP) is a chronic inflammatory disorder with a reported global prevalence of 0.5% to 2.6% and a 0 to 5.6% potential for malignant transformation into oral squamous cell carcinoma (OSCC), which accounts for over 90% of oral cancers and causes approximately 177,000 deaths annually worldwide. Identifying molecular markers that can distinguish high-risk OLP lesions is critical for early intervention. MicroRNA (miRNA) 146a has been implicated in inflammation-mediated carcinogenesis and may play a regulatory role in the progression from OLP to OSCC. Objectives: To evaluate and compare the expression of miRNA 146a in OLP and OSCC tissues and assess its diagnostic potential. Methods: Thirty formalin-fixed, paraffin-embedded (FFPE) tissue samples of well-differentiated OSCC and 18 samples of erosive OLP were retrospectively selected from the archives of Imam Khomeini Cancer Institute. These specific subtypes were included to minimize histopathological variability and ensure diagnostic consistency for accurate expression analysis. RNA was extracted and quantified using NanoDrop, followed by cDNA synthesis and qPCR using SYBR Green chemistry. ACTB was used as the reference gene for normalization. Expression analysis was conducted using REST 2009 software. Group differences were evaluated using the Mann-Whitney U test (P < 0.05). Results: The expression of miRNA 146a was significantly higher in OSCC (4.77 ± 4.54) compared to OLP (1.91 ± 0.96), with a P-value of 0.011, indicating its potential role as a biomarker for malignancy risk in OLP lesions. This corresponds to an approximate 2.5-fold increase in raw expression (non-log-transformed). Conclusions: The study identified a significant difference in miRNA 146a expression between OLP and OSCC samples. This suggests its potential use as a biomarker for distinguishing OLP from OSCC, though longitudinal studies are required to assess predictive value.
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The Effect of Branched-Chain Amino Acids (L-Valine, L-Leucine and L-Isoleucine) on Intestinal Morphology and IGF-1 Gene Expression in Broiler Chickens
(Brieflands, 2025-04-30) Shahriyar Khalilzadeh; Abolfazl Zarei; Nima Eila
Background: Insulin-like growth factor 1 (IGF-1) is an important regulator of growth, amino acid (AA) elongation, glucose metabolism, DNA synthesis, protein synthesis, and the proliferation and differentiation of various cell types. Therefore, IGF-1 may affect intestinal morphology by increasing nutrient uptake into intestinal enterocytes and promoting cell proliferation. Objectives: The present study aimed to evaluate the effects of different levels of branched-chain amino acids (BCAAs) (L-valine, L-leucine, and L-isoleucine) in low crude protein (CP) diets on intestinal morphology and IGF-1 gene expression in broiler chickens. Methods: A total of 480 one-day-old male and female broilers of the Ross 308 strain, with an average weight of 42.75 ± 0.47 g, were used. This experiment was carried out as a 3 × 2 factorial in the form of a completely randomized design with 6 treatments and 4 replications. The experimental diets included three levels of BCAA (0%, 10%, and 20% higher than the standard) and two levels of CP (standard or 10% lower than the standard). Results: Using 20% BCAA in the diet increased the villus height to crypt depth (VH/CD) ratio in the duodenum, jejunum, and ileum compared to the standard level of BCAA (P < 0.05). Reducing CP by 10% significantly lowered the VH/CD ratio in the duodenum, jejunum, and ileum (P < 0.05). The expression of IGF-1 mRNA in liver tissue was higher in the groups containing 10% BCAA than in the standard BCAA groups, regardless of the CP level. Conclusions: In general, BCAA supplementation could be beneficial for improving intestinal morphology and IGF-1 gene expression in broiler chickens on low CP diets.
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The Effect of Pulsed Electromagnetic Field Therapy on Fatigue, Depression, and Quality of Life in Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials
(Brieflands, 2025-01-31) Somaieh Ashrafi; Majid Barekatain; Fatemeh Rajabi; Shahrazad Mortazavi; Naghmeh Yazdi; Ali Shariat; Majid Barekatain [0000-0003-4001-6261]; Fatemeh Rajabi [0000-0003-0541-2250]
Background: Multiple sclerosis (MS) is a debilitating neurodegenerative condition characterized by various symptoms, particularly fatigue, which can significantly impact mental health and quality of life. Evidence regarding the efficacy of pulsed electromagnetic field (PEMF) therapy in managing certain symptoms of MS remains controversial. Objectives: This systematic review aimed to evaluate randomized clinical trials (RCTs) assessing the effects of PEMF therapy on fatigue, depression, and quality of life in individuals with MS. Methods: The electronic databases PubMed, Scopus, and Web of Science were searched for articles published between 1990 and 2023 using the keywords magnetic field therapy and MS. Two independent reviewers conducted the processes of screening, data extraction, and quality assessment. Fatigue was analyzed as the primary outcome, while depression and quality of life were considered secondary outcomes. Results: The search yielded 1,768 articles, of which 8 met the inclusion criteria for this review. A total of 372 participants were analyzed, 267 (71.7%) of whom were women. The intervention duration ranged from 3 to 12 weeks. Fatigue levels were reported in all included studies, while depression and quality of life were assessed in three studies. Conclusions: Compared to placebo, beneficial effects of PEMF therapy on fatigue severity were observed in only two studies, while the remaining studies showed no significant differences between groups. Furthermore, quality of life improved in only one study, and depression scores were comparable between groups at the end of all three studies. Additional trials with longer intervention durations, larger sample sizes, advanced technological devices, and objective assessment tools are needed to resolve this controversy.