The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).

Recent Submissions

Cardioprotective Effect of Hydroalcoholic Extract of Lepidium Draba on Isoproterenol-Induced Acute Myocardial Infarction in Rats.
(Brieflands, 2023-06-30) Maryam Kahyaei-Aaghdam; Vahid Shafiei-Irannejad; Sanaz Hamedeyazdan; Hamid Soraya
Background: Recently, there has been increased interest in medicinal plants for the discovery of new compounds to treat various disorders. A few studies have highlighted the antioxidant and anti-inflammatory effects of Lepidium draba (L. draba). Objectives: This study explores the potential cardioprotective effects of L. draba against myocardial infarction (MI) induced by isoproterenol. Methods: Isoproterenol (ISO) (100 mg/kg, injected subcutaneously for two consecutive days) was utilized to induce acute myocardial infarction in rats. The treated groups were administered hydroalcoholic extracts of L. draba intraperitoneally (ip) at doses of 50, 250, and 500 mg/kg for 2 consecutive days. Subsequently, the Electrocardiogram pattern, cardiodynamic parameters, cardiac remodeling, and lactate dehydrogenase levels were assessed. Results: The findings revealed that isoproterenol administration elevated the ST-segment and diminished the R-amplitude on the electrocardiogram, whereas treatment with L. draba extracts significantly ameliorated the ECG pattern. Isoproterenol injections lowered the mean arterial pressure (MAP), which was significantly increased by L. draba extract at all doses (P < 0.05). Furthermore, isoproterenol injections elevated lactate dehydrogenase (LDH) levels (P < 0.05) and cardiac fibrosis (P < 0.001), and treatment with the hydroalcoholic extract of L. draba significantly reduced both indices (P < 0.001 and P < 0.05, respectively). Conclusions: This study is the first to demonstrate that L. draba administration protects myocardial tissue from isoproterenol-induced infarction. Consequently, this plant could be recommended as an adjunct treatment for patients with acute MI.
The Influence of Foxp3 Treg Cell Gene Polymorphism (rs3761548) on FoxP3 Gene Expression in Patients with Chronic Hepatitis B Virus Infection
(Brieflands, 2024-12-31) Elnaz Rahimzadegan; Ameneh Elikaei; Zohreh Sharifi; Fatemeh Yari
Immune responses are pivotal in hepatitis B virus (HBV) infection, where Regulatory T cells (Treg) can contribute to sustaining the infection by suppressing immune responses. Forkhead box P3 (FoxP3) is the central regulator of Treg cells. In this case-control study, we investigated the role of FoxP3 -3279 (rs3761548) C/A polymorphism in the context of HBV infection. The study encompassed 140 healthy individuals as the control group and 70 individuals with chronic hepatitis B virus (CHBV) as the case group. The rs3761548 polymorphism was analyzed using the restriction fragment length polymorphism-PCR (PCR-RFLP) method. Furthermore, we evaluated FoxP3 gene expression in both HBV-positive and control groups using Real-Time PCR. The results revealed that the frequency of the AA genotype in the case and control groups was 52.9% and 44.3%, respectively, yielding an odds ratio (OR) of 1.411 with a 95% confidence interval (CI) ranging from 0.793 to 2.509. However, this difference did not achieve statistical significance (P = 0.242). Notably, the AC genotype was significantly more prevalent in the control group compared to the case group (P = 0.000). Moreover, FoxP3 gene expression was significantly higher in CHBV infection cases compared to the control group (P = 0.000). These findings suggest that the observed polymorphism may play a role in the pathogenesis and persistence of HBV infection. Nevertheless, further research is warranted to comprehensively investigate this phenomenon.
Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice
(Brieflands, 2024-02-28) Mohammad Javad Khodayar; Maryam Shirani; Mehrad Nikravesh; Elaheh Mohammadi; Laya Sadat Khorsandi; Saeedeh Shariati
Background: Sodium arsenite (NaAsO2) is a common mineral contaminant in drinking water in numerous parts of the world. It has been shown to have cardiovascular, metabolic, neuroendocrine, and urinary effects on the body. There is abundant scientific evidence that establishes a strong correlation between arsenic exposure and kidney-related disorders. Objectives: The present study aimed to investigate the potential protective effect of citicoline against NaAsO2-induced nephrotoxicity. Methods: The groups included a control group, a group treated with NaAsO2 at a concentration of 50 ppm, a group treated with Cit at a dosage of 1000 mg/kg, and three groups of NaAsO2 (50 ppm) co-treated with Cit at doses of 250, 500, and 1000 mg/kg, respectively. Results: Citicoline decreased the activity level of blood urea nitrogen (P < 0.001), creatinine levels (P < 0.001), thiobarbituric acid reactive substances (P < 0.001), nitric oxide (P < 0.001), inflammatory factors such as tumor necrosis factor-α (P < 0.001) and interleukin-6 (P < 0.001 and P < 0.001). Furthermore, Cit increased total thiol (P < 0.001) and activity levels of catalase (P < 0.05 and P < 0.001), superoxide dismutase (P < 0.01 and P < 0.001), and glutathione peroxidase (P < 0.001). Therefore, Cit reduced the harmful effects caused by the imbalance in oxidative and antioxidant systems and histopathological damage in NaAsO2-intoxicated mice, improving the damage caused by oxidative stress and inflammation. Conclusions: Our research indicates that Cit can shield the kidneys from the damaging effects of NaAsO2 by leveraging its antioxidant and anti-inflammatory properties.
Telemedicine and Pregnancy Care from the Perspective of Iranian Pregnant Women: A Study Based on the Technology Acceptance Model
(Brieflands, 2024-02-27) Leila Khademhosseini; Malihe Farid; Masoumeh Rajabi Naeeni; Mahnaz Akbari Kamrani
Background: It is apparent that telemedicine will only be a useful health service when individuals start using it. Therefore, the general attitude of end-users toward the acceptance of telemedicine services will play a significant role. Objectives: The present study is the first step in designing telemedicine services for pregnant mothers, with the aim of investigating the views of pregnant women regarding receiving tele-pregnancy care using the technology acceptance model (TAM). Methods: This cross-sectional study was conducted during the year 2021 on 200 pregnant women with gestational age of more than 12 weeks selected through simple random sampling in Karaj, Iran. The telemedicine acceptance questionnaire based on an extended TAM containing 25 questions in nine constructs was used to collect data. Descriptive statistics, including frequency, percentage, mean, and standard deviation (SD), were reported. Results: In this study, the mean age of the participants was 25.29 (SD = 5.62) years. A significant majority, specifically 95.5% of the participants, displayed a high level of acceptance toward incorporating telemedicine into their healthcare routine. In addition, the lowest mean scores of domains were related to technology anxiety, 26.18 (SD = 16.17), and perceived risk, 26.83 (SD = 16.26), respectively. Conclusions: Based on the TAM, the results of this study highlight the readiness and acceptance of pregnant women toward receiving tele-prenatal care.
Overexpression and Downregulation of HOTAIR Influence the Stemness Markers in Gastric Cancer Cell Lines
(Brieflands, 2024-02-28) Morteza Ghanadpour; Fatemeh Bossaghzadeh; Hamid Galehdari; Seyed Reza Kazemi Nezhad; Maryam Tahmasebi-Birgani; Mohammadreza Hajjari
Background: Several long non-coding RNAs are implicated in the development and metastasis of cancer. The non-coding RNA HOTAIR is known to play a significant role in the progression of various cancers. Objectives: This study aimed to assess the impact of HOTAIR dysregulation on stemness markers in AGS and MKN45 gastric cancer cell lines. Methods: Downregulation and upregulation of HOTAIR were induced using small interfering RNA (siRNA) and a HOTAIR overexpression vector, respectively. The surface stemness markers CD24 and CD44 were analyzed using flow cytometry. Additionally, the effects on the expression of two stemness markers, Nanog and P21, were investigated using Quantitative Reverse Transcription PCR (qRT-PCR). Results: Flow cytometry analysis showed that HOTAIR modulates the cell-surface expression of CD44 and CD24 in gastric cancer cells. Furthermore, dysregulation of HOTAIR significantly affected the expression of the genes P21 and Nanog. Conclusions: Our studies suggest that HOTAIR may regulate the stemness characteristics of gastric cancer cell lines.