Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands Repository

Select a community to browse its collections

Recent Submissions

Thumbnail Image
Item
Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin Loaded in Solid Lipid Nanoparticles and Curcumin in Atherosclerosis Therapy
(Brieflands, 2024-12-31) Masoumeh Shamsi; Ghorban Mohammadzadeh; Mahdi Hatami; Mohammadreza Roshanazadeh; Mojgan Noor-Behbahani; Mojtaba Rashidi
Background: Atherosclerosis remains the leading cause of mortality worldwide, highlighting the urgent need for innovative treatments targeting chronic inflammation. Recent research indicates that quercetin (quercetin) and curcumin, two naturally occurring compounds, have potential therapeutic benefits in cardiovascular diseases. Objectives: This study focuses on the novel synthesis of nano-quercetin (N-QCT) encapsulated in solid lipid nanoparticles (SLNs) and investigates the synergistic cardioprotective effects of N-QCT and curcumin on human vascular smooth muscle cells (VSMCs). The underlying molecular mechanisms, particularly the involvement of the TGF-β signaling pathway in VSMCs, are explored. Methods: The VSMCs, including TGF-β-stimulated VSMCs, were treated with N-QCT, curcumin, or a combination of both. The MTT assay was performed to evaluate the cytotoxic effects of these treatments. The cytotoxicity of various concentrations of curcumin and QCT was used to calculate the Combination Index (CI), with CI analysis quantifying synergy or antagonism. Furthermore, following TGF-β stimulation, antioxidant enzyme activity, nuclear transcription factor erythroid 2-related factor (Nrf2) mRNA expression, reactive oxygen species (ROS) production, NADPH oxidases (NOX) expression, and extracellular signal-regulated kinase (Erk)1/2 phosphorylation were measured in the treated VSMCs. Results: The N-QCT and curcumin significantly influenced Nrf2 mRNA expression and upregulated downstream antioxidant enzymes, including HO-1, GPx, and SOD1. The combination treatment further enhanced Nrf2 protein expression and modulated Erk1/2 phosphorylation. Notably, the synergistic effect of the combination produced pronounced cardioprotective outcomes, characterized by reduced ROS production and decreased phosphorylation of Erk1/2 via the TGF-β/NOX/Erk1/2 and ROS/Nrf2 signaling pathways. Conclusions: The findings demonstrate that the combination of QCT encapsulated in SLNs and curcumin synergistically reduces oxidative stress and inflammation in TGF-β-stimulated VSMCs. This effect is achieved through the inhibition of ROS/Erk1/2 signaling and the activation of Nrf2 and antioxidant enzymes. These natural compounds, when used together, represent a promising therapeutic approach for mitigating the inflammatory processes associated with atherosclerosis.
Thumbnail Image
Item
Women with Spinal Cord Injuries, Anxiety and Sexual Dissatisfaction: Do They Benefit from Sexual Rehabilitation Education?
(Brieflands, 2025-04-30) Mahnaz Seyedoshohadaee; Mahsa Soleimani; Hamid Haghani; Kosar Zeighami
Background: Spinal cord injury (SCI) affects all body systems, including physiological sexual responses, and negatively impacts sexual satisfaction and anxiety, leading to depression and damage to interpersonal relationships in couples. Therefore, sexual rehabilitation education by rehabilitation nurses is essential to prevent complications and improve performance. Objectives: This article aims to investigate the effect of sexual rehabilitation education on anxiety and sexual satisfaction among members of the Tehran Spinal Cord Injury Association. Methods: In this semi-experimental study, 100 women referred to the Tehran Spinal Cord Injury Association were randomly assigned to intervention and control groups. Data were collected using a demographic form, Beck's Anxiety Questionnaire, and Larson's Sexual Satisfaction Questionnaire. The data were analyzed using SPSS version 21 software and statistical tests, including chi-square, Fisher's exact test, and independent t-tests. Results: The mean anxiety score in the control group before and after the intervention was 19.66 and 20.68, respectively (P = 0.123), whereas in the intervention group, the mean scores were 20.92 and 18.04, showing a statistically significant reduction (P = 0.045). The mean sexual satisfaction score in the control group was 67.32 and 67.22, respectively (P = 0.912), while in the intervention group, it increased from 67.80 to 70.80, a statistically significant improvement (P = 0.010). Conclusions: The results of this study demonstrated that sexual rehabilitation education reduces anxiety and increases sexual satisfaction in women with spinal cord injuries. Implementing sexual rehabilitation education programs by nurses is an effective strategy to reduce anxiety and enhance the sexual satisfaction of women with spinal cord injuries.
Thumbnail Image
Item
Clinical Characteristics and Outcomes of COVID-19 in Pediatric Cancer Patients: A Retrospective Cohort Study
(Brieflands, 2024-12-11) Sara Badiepour; Sharareh Kamfar; Samin Alavi; Shahnaz Armin; Reza Taherian
Background: The impact of COVID-19 on pediatric cancer patients remains a critical area of investigation. Objectives: This study aimed to compare the clinical characteristics and outcomes of COVID-19 in children with and without malignancies. Methods: A retrospective cohort study was conducted at Mofid Children's Hospital in Tehran, Iran, from July 2020 to December 2022. The study included 210 children with confirmed SARS-CoV-2 infection: 105 with malignancies (case group) and 105 without malignancies (control group). Clinical presentations, laboratory parameters, imaging findings, and outcomes were analyzed. Results: Conclusions: Pediatric cancer patients with COVID-19 exhibited more severe symptoms and distinct laboratory and imaging findings compared to non-cancer patients. While mortality rates were similar, the trend toward higher risk in the malignancy group highlights the need for specialized management strategies for this vulnerable population.
Thumbnail Image
Item
A Grounded Theory Exploration of Perspectives, Underlying Factors, and Preventive Strategies of Online Sexual Abuse: A Stakeholders' View
(Brieflands, 2024-12-31) Hadi Gholamrezaei; Mohammad Reza Falsafinejad; Anahita Khodabakhshi-Koolaee
Background: Sexual abuse of children is a growing social concern, with online communication significantly facilitating access to vulnerable children and increasing the risk of sexual abuse, particularly on online platforms. Objectives: This study aimed to analyze the experiences, underlying factors, consequences, and preventive strategies of online sexual abuse from the perspectives of subject-matter experts. Methods: This qualitative grounded theory study was conducted in 2023 in Birjand, South Khorasan Province, Iran. The participants included 15 specialists in sex education who were selected through purposive sampling. Data were collected through in-depth semi-structured interviews until data saturation was achieved and were analyzed using Corbin and Strauss’s method. Results: Data analysis using the grounded theory approach revealed five main categories, ten axial codes, and 41 open codes: (1) Easy access to high-risk cyberspace, (2) failure to understand the potential risks of cyberspace (e.g., unsupervised content production and parents' preoccupation with personal concerns), (3) immaturity in social interactions (e.g., hidden shame and fear of discussing sexual issues, ineffective parent-child communication), (4) harms of unsupervised cyberspace (e.g., psycho-social harm and early sexual awakening), and (5) awareness and clarification as keys to preventive support (e.g., raising parental awareness, providing parental education, and seeking professional counseling support). Conclusions: Knowledge about online child sexual abuse in Iran is limited. The findings from this study provide valuable insights that can contribute to the development of effective strategies for preventing online sexual abuse in children and adolescents.
No Thumbnail Available
Item
Information Requirements of Clinical Decision Support Systems for the Diagnosis and Prediction of Preeclampsia
(Brieflands, 2024-12-11) Nazanin Khayatan; Nasim Aslani; Ali Garavand; Nasrin Galehdar; Vadad Khayatan
Background: Clinical decision support systems (CDSS) are valuable tools for diagnosing and predicting diseases. However, their effectiveness hinges on the quality of the information provided. Objectives: This study aimed to identify the information requirements for a CDSS designed to diagnose and predict preeclampsia. Methods: This applied study was conducted in 2024. A literature review was performed to identify relevant studies. Based on the findings, a questionnaire with a five-point Likert scale was developed and validated through the input of 22 experts in related fields. Data were analyzed using SPSS version 22, and the findings are presented in the text and tables. Results: Among 143 items identified, 115 were deemed essential for a CDSS to diagnose and predict preeclampsia. The information requirements were classified into eight main categories: Demographic information, medical history, laboratory data, pregnancy-related data, complications in other organs, medical examinations, warning signs, paraclinical data, and lifestyle. Conclusions: The findings of this study provide critical insights for developers of CDSS tailored to preeclampsia diagnosis and prediction. By addressing these information needs, such systems can significantly enhance the capabilities of women's health professionals, advancing timely diagnosis and prevention of preeclampsia.