Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

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The Effectiveness of Logotherapy on Marital Sexual Function and Hope in Individuals with Spinal Cord Injuries
(Brieflands, 2025-03-31) Ashraf Bagheri; Alireza Heidari; Farah Naderi; Ashraf Bagheri [0009-0003-5351-3686]; Alireza Heidari [0000-0001-8974-3211]; Farah Naderi [0000-0001-5801-5967]
Background: Spinal cord injuries, arising from traumatic events, pathological conditions, or iatrogenic surgical complications, exert profound and multifaceted impacts on patients' lives. Objectives: This study aimed to determine the efficacy of logotherapy on marital sexual function and hope in individuals with spinal cord injuries. Methods: This study employed a quasi-experimental pre-test-post-test control group design. The target population consisted of individuals with spinal cord injuries residing in Ahvaz, Iran, during 2023. A convenience sample of 30 participants, with 15 assigned to each group, was selected based on predetermined inclusion criteria and subsequently randomized to either the experimental or control condition. The experimental group received eight 90-minute sessions of logotherapy. Both groups completed the Marital Sexual Function Scale and the Miller Hope Scale at baseline and post-intervention. Data were analyzed using Mann-Whitney U tests. Results: The findings demonstrated that logotherapy resulted in statistically significant enhancements in both marital sexual function and hope among individuals with spinal cord injuries, as evidenced by pre- to post-test assessments (P < 0.001). Conclusions: Logotherapy was found to significantly improve marital sexual function and hope in individuals with spinal cord injuries. This suggests that logotherapy is an effective intervention for addressing both physical and psychological challenges associated with spinal cord injury. Future research should investigate the long-term effects and mechanisms of logotherapy in this population.
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Interleukin 10 Cytokine Polymorphism (rs1800896) Association with the Hepatitis C in Patients from Iraq
(Brieflands, 2025-12-31) Amel Mohan AL-Shihani; Mohammad Khalaj-Kondori; Asmaa Mohammed Saud; Mohammad Khalaj-Kondori [0000-0001-9231-889X]
Background: Hepatitis C virus (HCV) is a significant international health concern. T-helper (Th)-2 cells secrete the anti-inflammatory cytokine interleukin 10 (IL-10) to regulate the humoral immune response. Objectives: This study aims to investigate the IL-10 cytokine gene polymorphism rs1800896 and its potential associations with various aspects of viral infection and susceptibility to chronic HCV infection. Methods: In this case-control study, 180 participants were enrolled from the Digestive and Liver Diseases Teaching hospital in Baghdad Medical city during 2023 and 2024. The study included 100 individuals with HCV infection and 80 healthy controls. Blood samples were collected, and genomic DNA was extracted using the ReliaPrepTM blood g-DNA mini-prep system. The IL-10 target sequence was amplified using polymerase chain reaction (PCR) and genotyped by sequencing. Results: Significant differences in genotype frequencies of IL-10 rs1800896 were observed between the HCV patient and control groups for the AA and AG genotypes (P = 0.046, P = 0.009, respectively). A dominant model AG + GG genotype showed a correlation with HCV susceptibility compared to the AA genotype, with an OR of 1.93 (95% CI; 1.60 to 3.52). Furthermore, the over-dominant model indicates that individuals with the AG genotype have a significantly higher likelihood of developing HCV compared to those with the AA + GG genotypes (OR = 2.33, 95% CI: 1.26 - 3.31). No statistically significant associations were found between the genotypes GG, AG, and AA and demographic characteristics. Conclusions: The presence of a dominant or over-dominant model suggests that the IL-10 gene rs1800896 polymorphism may contribute to susceptibility to HCV. Further investigation into the links between IL-10 and Hepatitis C is warranted.
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Prognostic Factors of Patients with Decompensated Hepatitis B Cirrhosis and Establishment of a Risk Prediction Model
(Brieflands, 2025-12-31) Hua Jiang; Fei Wu; Wenkai Peng; Cong Wang
Background: We aimed to explore the prognostic factors in patients with decompensated hepatitis B cirrhosis (HBC) and to establish a risk prediction model. Methods: In this prospective study, 120 subjects were selected from patients with decompensated HBC who were hospitalized between January 2022 and January 2023. All patients were followed for one year. Using death during follow-up as the prognostic endpoint, patients were categorized into a good prognosis (survival) group and a poor prognosis (death) group. Demographic data and laboratory indicators were compared between the two groups. Risk factors were identified using multivariate logistic regression analysis, and a risk prediction model was subsequently established. Results: There were 30 cases (25%) in the poor prognosis group and 90 cases (75%) in the good prognosis group. The incidence of hypoproteinemia, international normalized ratio (INR), and the levels of total cholesterol (TC), cell-free deoxyribonucleic acid (cfDNA), and granulocyte-macrophage colony-stimulating factor (GM-CSF) were significantly higher in the poor prognosis group compared to the good prognosis group (P < 0.05). Hypoproteinemia, cfDNA, GM-CSF, and INR were identified as risk factors for poor prognosis in patients with decompensated HBC [odds ratio (OR) > 1, P < 0.05], while TC was identified as a protective factor (OR < 1, P < 0.05). A regression equation was established as follows: Conclusions: Hypoproteinemia, INR, cfDNA, and GM-CSF are risk factors for poor prognosis in patients with decompensated HBC.
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Effectiveness of Training Ethical Principles in Clinical Trials on the Awareness of Health Professionals
(Brieflands, 2025-06-30) Amir Rauf; Ideh Dadgaran; Hamid Mohammadi Kojidi; Saeed Biroudian; Kourosh Delpasand; Kourosh Delpasand [0000-0001-6842-3374]
Background: Adherence to ethical and legal principles in clinical trials leads to the improvement of the quality of patient treatment, reduction of complications caused by interventions, improvement of the scientific level of published articles, and increased generalizability of studies to the general population. Objectives: The present study evaluated the role of training in ethical principles on health professionals’ awareness status. Methods: This clinical trial included 50 health professionals from the Guilan University of Medical Sciences, Rasht, Iran, in 2022. The status of awareness of applying ethical principles in clinical trials was assessed using a self-designed questionnaire, scoring from 0 to 10. Participants’ personal and educational data were recorded, and data were analyzed using SPSS version 26. The significance level was set at 0.05. Results: The study involved health professionals in different fields with a mean age of 41.88 ± 12.58 years. Participants were predominantly female (46%), held PhD.s (40%), were nurses (30%), and faculty members (58%). Awareness scores significantly increased from 5.16 ± 1.57 pre-workshop to 8.62 ± 0.99 post-workshop (P < 0.001). Significant improvements were observed across age groups, genders, and most educational levels and medical specialties (P < 0.05), while no statistically significant association was observed between subgroups and awareness score (P > 0.05). Conclusions: The study demonstrated the effectiveness of the ethical principles workshop in enhancing awareness of research ethics principles among diverse healthcare professionals.
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Evaluation of Antimicrobial Activity of Novel Chimeric M-PEX12 Peptide Against Acinetobacter baumannii
(Brieflands, 2025-12-31) Yasin Rakhshani; Hamideh Mahmoodzadeh Hosseini; Seyed Ali Mirhosseini; Fatah Sotoodehnejadnematalahi; Jafar Amani; Hamideh Mahmoodzadeh Hosseini [0000-0002-3987-0164]; Jafar Amani [0000-0002-5155-4738]
Background: Acinetobacter baumannii-induced nosocomial pneumonia and its associated biofilm infections pose significant clinical challenges due to high rates of antibiotic resistance. Traditional antibiotic treatments encounter numerous obstacles, making antimicrobial peptides (AMPs) a promising alternative for controlling such pathogens. The emergence of multidrug-resistant strains necessitates the exploration of innovative therapeutic strategies. Objectives: We recently designed a novel hybrid peptide, M-PEX12, which exhibits antimicrobial activity and low toxicity in vitro. To confirm its therapeutic potential, we evaluated it in both in vitro and in vivo settings. Methods: M-PEX12 was evaluated using time-kill kinetics, thermal stability, reactive oxygen species (ROS) generation, biofilm inhibition assays, scanning electron microscopy (SEM), cytotoxicity tests, and virulence gene expression analysis. Its in vivo activity against A. baumannii was also assessed in an animal model. Results: The time-kill kinetics assay indicated that exposure to M-PEX12 at 1x minimum inhibitory concentration (MIC) (33/154) and 2x MIC resulted in over 95% reduction in bacterial populations within 30 minutes. Notably, the bacteria did not develop resistance to increased temperatures. M-PEX12 effectively disrupted biofilm formation at various concentrations. Field emission SEM revealed significant ultrastructural deformities in A. baumannii cell walls. Treatment with M-PEX12 increased production of intracellular ROS and decreased cell viability in a concentration-dependent manner. Cytotoxicity assays showed no significant effect on HEK293 cell viability. Additionally, expression levels of omp33, csuE, bfmR, and ompA were significantly reduced. The antimicrobial efficacy of M-PEX12 was confirmed in vivo. Conclusions: M-PEX12 exhibited significant antimicrobial activity and low toxicity in a mouse model, suggesting its potential as a treatment for drug-resistant bacterial infections.