Brieflands
History
The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.
Business Profile
- Brieflands is a Registered Trademark with record number 1454012.
- Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
- KvK number: 89235444.
- BTW (VAT) number: NL864918896B01 (check online at VIES)
- RSIN: 864918896
- Nedmedica is our related company which is specialized in Author Services.
- Our former branding name was Kowsarmedical Publishing (2010-2021).
Communities in Brieflands
Select a community to browse its collections.
Recent Submissions
Comparison of Preoperative Ketamine, Lidocaine, and Magnesium (KLM) Cocktail Versus Morphine for Postoperative Pain Management in Opioid-abuser Patients Undergoing Distal Radius Fracture Surgery: A Double-Blinded Randomized Clinical Trial
(Brieflands, 2025-06-30) Hamidreza Azizi Faresani; Hossein Niazi; Houman Teymourian; Hamidreza Azizi Faresani [0000-0002-4561-6066]; Houman Teymourian [0000-0002-0102-4106]
Background: Effective postoperative pain management is critical for patient recovery, particularly in opioid-abuser individuals undergoing distal radius fracture surgery. Multimodal analgesia, including preoperative ketamine, lidocaine, and magnesium (KLM) combinations, has emerged as a promising alternative to reduce opioid consumption while effectively controlling pain. Objectives: This study compares the efficacy and safety of a preoperative KLM cocktail versus morphine for postoperative pain management in opioid-abuser patients undergoing distal radius fracture surgery. Methods: Sixty eligible patients [aged 18 - 65, with a history of opium use (1 - 5 g/day)] were randomly allocated (1:1 ratio) into two groups: The KLM group received intravenous (IV) lidocaine (1.5 mg/kg), magnesium (30 mg/kg), and ketamine (0.3 mg/kg) diluted in 50 mL of 0.9% normal saline, administered over 15 minutes preoperatively. The morphine (M) group received IV morphine (0.1 mg/kg) in 50 mL of 0.9% normal saline over the same duration. Postoperative pain was assessed using the Visual Analog Scale (VAS) upon PACU arrival and at 3, 6, 12, and 24 hours post-surgery. Secondary outcomes included 24-hour opioid consumption, adverse effects, and patient satisfaction scores. Results: The KLM group demonstrated significantly lower pain scores on the Numerical Rating Scale (NRS) at all-time points compared to the morphine group (P < 0.05). Additionally, total opioid consumption was 40% lower in the KLM group, with a reduction in opioid-related adverse effects such as nausea and sedation. Patient satisfaction scores were also significantly higher in the KLM group. Conclusions: Preoperative KLM cocktail administration is more effective than morphine in managing postoperative pain in opioid-abuser patients undergoing distal radius fracture surgery. This multimodal approach reduces pain scores, opioid consumption, and adverse effects while improving patient satisfaction. Further research is needed to validate its long-term efficacy and safety across diverse surgical populations.
The Similarity of a Critical Quality Study Among the Ciplukan Extract Capsule from A Laboratory Setting and a Pilot Scale in a Partner Industry
(Brieflands, 2025-12-31) Yoga Windhu Wardhana; Raden Bayu Indradi; Ade Zuhrotun; Rini Hendriani; Enny Rohmawaty; Winda Saragih; Savira Ekawardhani; Hesti Lina Wiraswati; Sumartini Dewi; Yoga Windhu Wardhana [0000-0002-4337-899X]; Raden Bayu Indradi [0000-0002-2223-6925]; Ade Zuhrotun [0000-0002-7451-9118]; Rini Hendriani [0000-0002-1537-7906]; Enny Rohmawaty [0000-0002-4232-3727]; Winda Saragih [0000-0003-3204-4318]; Savira Ekawardhani [0000-0002-8904-7811]; Hesti Lina Wiraswati [0000-0003-2462-6633]; Sumartini Dewi [0000-0002-6467-7964]
Background: Differences in pharmaceutical product processing and equipment between laboratory development and industrial scale-up can result in dramatically variable quality. Therefore, the quality similarities across pharmaceutical dosage forms must be tested at several facilities. Similarities in the quality of dosage forms for pharmacological treatment derived from herbal ingredients from development and production scale are often overlooked, and no one has published them yet. Methods: A two-level factorial experimental design was used in the laboratory for formulation optimization, with variations in the composition of colloidal silicon dioxide and starch glycolate salts. Quality responses included loss on drying (LOD), flowability, angle of repose, uniformity of capsule weight, and disintegration time. The same responses as the performance of similarity attributes were also evaluated on pilot-scale items from partner businesses. Results: The overall quality response of the tested product met the standards for fine granules and capsules. The composition with the highest attractiveness, according to the program, was F4 at 0.686, based on a pilot-scale formulation at partner industrial facilities. According to a Jaccard similarity of 0.88, the quality test results were quite comparable. A total plate number test was performed to assess the safety of microbiological contamination throughout the processing of all goods, yielding a result of 7.07 × 104, which is still in conformity with the standards of the Indonesian Food and Drug Administration (FDA), namely 107. Conclusions: The Jaccard similarity index for capsule manufacture at two different manufacturing sites is 0.88, indicating an excellent resemblance. This suggests that the process may be repeated in larger quantities.
A Comparison of the Lateral Approach (Paramedian) Versus the Modified Lateral Approach (Modified Paramedian) in Spinal Anesthesia: Evaluating Ease of Procedure and Patient Satisfaction in Urological Surgeries; A Triple-Blind Randomized Clinical Trial
(Brieflands, 2025-06-30) Mehrdad Mesbah Kiaei; Siavash Sangi; Maryam Aligholizadeh; Mahmoud Reza Mohaghegh Dolatabadi; Ali Moshki; Mohsen Abbasi; Mehrdad Mesbah Kiaei [0000-0002-8908-054X]; Siavash Sangi [0000-0002-7833-0021]; Maryam Aligholizadeh [0009-0009-7760-683X]; Mahmoud Reza Mohaghegh Dolatabadi [0000-0001-6079-2589]; Ali Moshki [0009-0002-9902-8240]; Mohsen Abbasi [0000-0003-3227-9133]
Background: Spinal anesthesia (SA) is preferred over general anesthesia for lower extremity surgeries, but the optimal method of needle placement is debated. Although the paramedian approach reduces the risks of dural puncture, it presents technical difficulties. The modified paramedian technique may increase safety and patient satisfaction by facilitating subarachnoid access and overcoming anatomical challenges, particularly in obese or elderly patients. Objectives: This study aimed to compare the paramedian and modified paramedian techniques from the perspective of anesthesiologists and their impact on postoperative patient satisfaction. Methods: This triple-blind randomized clinical trial investigated the effects of two SA techniques — paramedian and modified paramedian — on patient satisfaction and procedural ease. A total of 112 patients meeting inclusion and exclusion criteria were enrolled. Data were collected using the Iowa Satisfaction with Anesthesia Care Questionnaire. Demographic information was recorded in coded form, and data analysis was performed using SPSS version 19. Statistical methods included the independent t-test for comparing continuous means between groups, the chi-square test for categorical variables, and logistic regression analysis to assess the impact of individual characteristics (age, gender, weight) on the ease of performing spinal anesthesia. Results: The results indicated that the modified paramedian group demonstrated superior performance in terms of success on the first attempt (P = 0.006), reduced need for repositioning (P = 0.038), and fewer repeated attempts (P = 0.017). Additionally, patient satisfaction scores were significantly higher in the modified paramedian group (P = 0.001). Multivariate regression confirmed age and Body Mass Index (BMI) as independent predictors of procedural difficulty (P < 0.05). Conclusions: The modified paramedian technique significantly enhanced the ease of SA administration and patient satisfaction compared to the traditional approach. These findings indicate its potential to improve the anesthesia process, reduce side effects, and elevate patient experience. This study supports broader adoption of the technique in surgical and healthcare settings, advancing anesthesia care quality.
The Effect of Foot Reflexology on the Level of Fatigue, Dyspnea and Anxiety of Chronic Respiratory Patients
(Brieflands, 2024-10-31) Motahareh Mousavi Ghahfarokhi; Sadaf Bazzaz; Maede Roumiani; Zahra Rahmaniseimare; Mohammad Kogani; Motahareh Mousavi Ghahfarokhi [0000-0003-2751-3394]; Sadaf Bazzaz [0009-0005-7991-5696]; Maede Roumiani [0009-0008-3629-4780]; Zahra Rahmaniseimare [0009-0007-1616-5589]; Mohammad Kogani [0000-0003-4283-3441]
Background: Chronic respiratory diseases are among the most common non-communicable diseases globally. Foot reflexology may offer benefits for patients with these conditions. Objectives: This study aimed to assess the impact of foot reflexology on anxiety, dyspnea, and fatigue in patients with chronic respiratory diseases. Methods: A quasi-experimental clinical trial was conducted with 34 chronic respiratory patients (moderate to severe lung involvement) from Abadan University of Medical Sciences-affiliated hospitals. Participants were selected through purposive sampling. Reflexology sessions were administered twice a week for six weeks, each lasting 30 minutes, using sweet almond oil. Data were collected through a Socio-demographic Questionnaire, Spielberger State-Trait Anxiety Inventory, Fatigue Severity Scale, and Borg Dyspnea Scale. Results: After foot reflexology, significant reductions were observed in fatigue, dyspnea, and anxiety scores (P < 0.05). Multivariable regression analysis, controlling for confounders, confirmed these reductions in the intervention group. Conclusions: Foot reflexology is a beneficial complementary treatment alongside conventional medical care for chronic respiratory patients.
Lazy Adrenals in Severe Hypothyroidism - Myth or Mirage?
(Brieflands, 2025-04-30) Swaraj Waddankeri; Meenakshi Swaraj Waddankeri; Swaraj Waddankeri [0000-0003-4228-7372]; Meenakshi Swaraj Waddankeri [0000-0003-0561-9462]
Background: Clinical features of hypothyroidism and adrenal insufficiency (AI) often overlap. Objectives: To assess the morning serum cortisol levels of treatment-naïve patients with severe hypothyroidism. Methods: In this prospective, case-control study, treatment-naïve adults with severe hypothyroidism [thyroid-stimulating hormone (TSH) > 100 mIU/mL] were compared with age- and sex-matched euthyroid controls. Morning (08:00 AM) serum cortisol, TSH, triiodothyronine (T3), and thyroxine (T4) levels were measured. AI was defined clinically and biochemically as cortisol levels < 4 µg/dL. Correlation coefficients between T3, T4, and cortisol levels were calculated. Results: The case group (n = 71; women, 88.7%; mean age, 30.0 ± 9.0 years) had significantly lower serum cortisol levels than controls (n = 40; 8.6 ± 4.2 vs 16.0 ± 2.22 µg/dL; P < 0.0001). Six patients (8.5%) in the case group met criteria for AI. Patients with AI had significantly lower T3 and T4 levels than those without AI (P = 0.018 and P = 0.005, respectively). A negative correlation was observed between T3 and cortisol levels (r = -0.243, P = 0.041), while T4 showed no significant correlation (r = -0.103, P = 0.391). Conclusions: Treatment-naïve patients with severe hypothyroidism may exhibit biochemical evidence of AI. Routine screening for AI in these patients is recommended to avoid missed diagnoses and guide appropriate therapy.