Brieflands

History

The company was first founded by Seyyed M. Miri and Seyed-M Alavian as an editorial group in a Medical Institute in 2007 to publish its medical journal. After three years of experience, the number of journals increased to 5 journals, and the company launched its first form of business as a VOF (collaboration) professional STM company in Heerlen, the Netherlands, which was called "Kowsarmedical Publishing." Respecting the publishing services (from submission to publishing), especially an in-house "Journal Management System," our journals increased to more than 60 STM journals between 2010 and 2019. Since 2022, "Brieflands" is the new brand name that acts as a "Science, Technical, Medical Publisher" that publishes more than 50 journals with the services provided by 97 expert employees in three different branches.

Business Profile

  • Brieflands is a Registered Trademark with record number 1454012.
  • Brieflands has been registered as a General partnership (Vennootschap onder firma) company in the Chamber of Commerce (Kamer van Koophandel) of the Netherlands since 2010.
  • Nedmedica is our related company which is specialized in Author Services. 
  • Our former branding name was Kowsarmedical Publishing (2010-2021).
 

Communities in Brieflands

Select a community to browse its collections.

Recent Submissions

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Systemic Hyperthermia Combined with Chemotherapy: A Pilot Clinical Trial in the Treatment of Metastatic Gastrointestinal Cancers
(Brieflands, 2025-12-31) Mohammad Ali Broomand; Maryam Kalantari Khandani; Saleh Sandoughdaran; Hamidreza Mirzaei; Mohammad Ali Broomand [0000-0002-1208-4470]; Maryam Kalantari Khandani [0009-0003-1740-1636]
Background: Hyperthermia, which involves heating body tissues to enhance cancer treatment efficacy, has been explored as an adjunctive therapy to improve chemotherapy outcomes. Whole-body hyperthermia (WBH) offers a potential synergistic approach by sensitizing cancer cells to chemotherapeutic agents and enhancing drug delivery. Objectives: This study aimed to evaluate the efficacy and safety of combining systemic chemotherapy with WBH in patients with metastatic gastrointestinal cancers. Methods: A pilot study was conducted at Shohada Tajrish Hospital. Patients with pathologically confirmed metastatic gastrointestinal cancers were treated with standard systemic chemotherapy combined with WBH. Hyperthermia was applied using infrared devices, maintaining body temperatures between 39°C and 40.5°C. Patients were kept at this plateau for 1.5 hours, receiving chemotherapy concurrently. Chemotherapy drugs were administered at 80% of the standard dose. After the completion of WBH, patients were observed in the hospital for 24 hours to ensure safety. Data on patient demographics, tumor characteristics, chemotherapy regimens, and adverse events were systematically collected and analyzed. Results: A total of 20 patients (mean age: 54.8 years) participated in the study, with an equal distribution of male and female participants. The mean number of hyperthermia and chemotherapy cycles was 4.6 and 4.9, respectively. Clinical response rates included 5% (1 patient) with a complete response (CR), 40% (8 patients) with a partial response (PR), and 35% (7 patients) with stable disease (SD). The overall disease control rate (DCR) — comprising CR, PR, and SD — was 80%, and all responses were observed in patients who had received at least six cycles of hyperthermia. Conclusions: Whole-body hyperthermia combined with chemotherapy is a viable and well-tolerated therapeutic strategy for metastatic gastrointestinal cancers, demonstrating a favorable toxicity profile and promising response rates.
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Comparison of Single Intraoperative Dose of Dexamethasone on Glycemic Profile in Postoperative Diabetic and Non-diabetic Patients
(Brieflands, 2025-04-30) Shetty Shyvi Ravindra; Ahlam Abdul Rahman; Rashmi R. Aithal; Sonal Bhat; Akshatha D.; Shetty Shyvi Ravindra [0009-0005-4348-8397]; Ahlam Abdul Rahman [0009-0008-3507-3986]; Rashmi R. Aithal [0009-0004-8605-9755]; Sonal Bhat [0000-0003-1579-9436]; Akshatha D. [0009-0007-8062-8939]
Background: This is a prospective observational study. Dexamethasone is commonly associated with postoperative hyperglycemia. There is limited data on the glycemic effect of dexamethasone among the diabetic population. Objectives: In the current investigation, postoperative glucose levels were measured in both diabetic and non-diabetic individuals, and then a single dose of intraoperative dexamethasone was administered. Methods: A total of 86 participants, with ASA I/II, were categorized into two groups: Diabetic and non-diabetic. Each group consisted of 43 individuals. The participants' ages ranged from 18 to 70 years. During the operation, a single dosage of dexamethasone, with a maximum of 8 milligrams, was provided intraoperatively. “Postoperative nausea and vomiting” (PONV), random blood glucose (RBG), and pain ratings were recorded before surgery, immediately after surgery, after 12 hours, and 24 hours following surgery. Preoperative blood glucose levels were also recorded. The “Chi-square test and the unpaired t-test” were used for comparison and to analyze the data. A significance level of P < 0.05 was deemed significant. Results: There was a statistically significant variance in RBG levels between diabetics and non-diabetics (P = 0.001). At various time periods, there was no correlation between the severity of PONV and diabetes among the participants. At various time intervals, the length of the procedure and the pain levels were equivalent to one another. In each group, there was a significant rise in RBG up to 12 hours, followed by a decline after 24 hours to a level similar to preoperative values. Conclusions: A single dose of intraoperative “dexamethasone” was associated with transient hyperglycemia postoperatively up to 12 hours, which was more pronounced among the diabetic population and without major adverse effects like PONV in either group.
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Linking Self-compassion to Suicidal Ideation: Mediating Effects of Resilience and Moderating Effects of Social Support in Emerging Adult
(Brieflands, 2025-06-30) Husnul Khotimah; Agustin Rahmawati; Al Thuba Septa Priyanggasari; Dellawaty Supraba; Husnul Khotimah [0009-0009-3218-6229]; Agustin Rahmawati [0000-0003-4420-6601]; Al Thuba Septa Priyanggasari [0000-0003-0870-9121]; Dellawaty Supraba [0009-0006-2119-8513]
Background: Emerging adulthood is a critical period marked by significant life changes and psychological challenges, including an increased risk of mental health issues and suicidal ideation. This study explores the interaction between self-compassion, resilience, and social support in reducing suicidal thoughts among young adults. Self-compassion plays a crucial role in enhancing mental well-being, resilience aids individuals in coping with emotional challenges, and social support can amplify the positive effects of self-compassion on reducing suicidal ideation. Objectives: The present study aims to investigate how social support moderates and resilience mediates the relationship between self-compassion and suicidal ideation among emerging adults. Patients and Methods: A cross-sectional study was conducted using the Self-compassion Scale (SCS), Connor-Davidson Resilience Scale (CD-RISC), Social Provision Scale (SPS), and Revised-Suicidal Ideation Scale (R-SIS). Data were collected from 309 emerging adults (ages 18 - 29) in Indonesia in 2024 through an online survey. Participants were informed about the study’s purpose and their rights to ensure ethical consent. Data analysis was performed using IBM SPSS version 26.0 with Hayes PROCESS Macro Model 8. Results: The results indicated that self-compassion was positively related to resilience (Coef = 0.24, P < 0.001) and negatively related to suicidal ideation (Coef = -0.25, P < 0.001). Resilience was also negatively associated with suicidal ideation (Coef = -0.37, P < 0.001). Social support strengthened the relationship between self-compassion and suicidal ideation (Coef = 0.02, P < 0.001), and resilience mediated the relationship between self-compassion and suicidal ideation (Coef = -0.09). This suggests that self-compassion can enhance resilience, thereby reducing suicidal ideation. Conclusions: The study indicated that self-compassion enhances resilience and reduces suicidal ideation, with social support further strengthening this relationship. The findings suggest that mental health interventions incorporating self-compassion and social support may be more effective in preventing suicidal ideation. This study also highlights the need for further research using more representative sampling techniques to obtain generalizable results.
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Respiratory Syncytial Virus Enhances SIRT2 Expression Through Wnt/β-Catenin Signaling to Promote Lung Cancer Progression
(Brieflands, 2025-05-31) Wei Cao; Hang Li; Kui Fan; Wulan Tuya
Background: The Wnt/β-catenin signaling pathway is a key regulator of cellular processes, with its dysregulation implicated in various cancers, including lung cancer. Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase, has emerged as a potential downstream target of this pathway. Objectives: The present study explores the regulation of SIRT2 expression by Wnt/β-catenin signaling and respiratory syncytial virus (RSV) infection, and their roles in lung cancer progression. Methods: Five hundred forty-nine lung cancer cells and MRC5 normal lung cells were used to investigate the interplay between RSV infection, Wnt/β-catenin signaling, and SIRT2. Expression levels of SIRT2 and β-catenin were assessed by Western blotting, real-time PCR, and confocal microscopy. The impact of Wnt3a (activator), XAV939 (inhibitor), and SIRT2 modulation on cell proliferation, oncogenic marker expression, and apoptosis were evaluated. Results: Wnt3a treatment increased SIRT2 and β-catenin expression at transcriptional and protein levels in A549 cells, while XAV939 reversed this effect. The RSV infection synergistically enhanced SIRT2 expression, with Wnt3a amplifying the effect and XAV939 inhibiting it. Confocal microscopy revealed RSV-induced cytoplasmic accumulation of SIRT2 and β-catenin. The SIRT2 overexpression augmented RSV- and Wnt3a-mediated proliferation and increased cyclin D1 expression, while SIRT2 knockdown suppressed these effects. Sirtuin 2 and Wnt/β-catenin signaling synergistically upregulated Ki-67, Snail, and c-Myc, promoting tumor progression. SIRT2 enhanced anti-apoptotic markers (Bcl-2) and inhibited pro-apoptotic markers (cleaved caspase-3 and PARP). The SIRT2 knockdown reversed these effects, inducing apoptosis. Conclusions: The RSV infection activates the Wnt/β-catenin pathway to upregulate SIRT2, which promotes lung cancer progression by enhancing cell proliferation, oncogenic marker expression, and anti-apoptotic activity. Targeting SIRT2 and its regulatory pathways offers a promising therapeutic strategy for combating lung cancer.
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Chronic Osteomyelitis of the Left Tibia Caused by Pseudomonas luteola: A Case Report
(Brieflands, 2025-05-31) Wenshuai Li; Chang Yu; Fei Tan; Wen Song; Zhiqiang Lin; Qiuming Gao
Introduction: Pseudomonas luteola is a rare pathogen that was classified as a separate genus in 1987. It is highly resistant to drugs and is primarily found in soil, water, and moist environmental areas, rarely infecting humans. Case Presentation: In this study, the pathogenic bacterium P. luteola was isolated from the necrotic material and secretions of a patient with chronic osteomyelitis of the left tibia. Notably, its susceptibility to gentamicin in this study differed from previous reports. Conclusions: Pseudomonas luteola is generally susceptible to gentamicin; however, in this case, it demonstrated resistance to gentamicin.