Prevalence of Hepatitis C Virus, Hepatitis B virus, Human Immunodeficiency Virus and Related Risk Factors Among Hemophilia and Thalassemia Patients in Iran
| Author | Hamid Kalantari | en |
| Author | Ahmad Mirzabaghi | en |
| Author | Mojtaba Akbari | en |
| Author | Zahra Shahshahan | en |
| Issued Date | 2011-04-30 | en |
| Abstract | Objectives: This study was conducted to assess the prevalence of Hepatitis C virus (HCV), Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV) among hemophilia and thalassemia patients. Patients and Methods: Present study was conducted from October 2008 to December 2010 in Isfahan, Iran. One thousand one hundred and sixty adult multi-transfused patients (822 males, 338 females, mean age 22.711.5 years) suffering from beta-thalassemia (n = 545) and hemophilia (n=615) were enrolled in the study. Blood samples were obtained from the patients and were tested for HBs Ag, Anti-HCV Ag and Anti- HIV Ab. HCV positive patients underwent genotype determination. Results: Of 545 thalassemia patients, 312(57.2%) were male and 233 (42.8%) were female. From 615 hemophilia : patients, 511(83%) were male and 104 (17%) were female. Chronic hepatitis was detected in 505(82.1%) hemophilia patients of which 495 (98%) were HCV Ab positive and 10 (2%) had HBsAg positive. The prevalence of HCV Ab positive and HBsAg positive in 56 (11%) thalassemia patients with chronic hepatitis was 50 (89.2%) and 6 (10.8%) respectively. None of the thalassemia and hemophilia patients were positive for HIV Ab. History of hepatitis in family is the major risk factors and HCV genotype 1 was the major genotype in our patients. Conclusion: HCV is the major virus of concern in multi-transfused patients. The strategies for prevention of HCV, HBV and HIV and safety of blood products in this respect have indeed been successful. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/archcid/articles/78601 | en |
| Keyword | Transfusion | en |
| Keyword | Blood-Borne Pathogens | en |
| Keyword | Chronic Hepatitis | en |
| Keyword | Thalassemia | en |
| Keyword | Hemophilia. | en |
| Publisher | Brieflands | en |
| Title | Prevalence of Hepatitis C Virus, Hepatitis B virus, Human Immunodeficiency Virus and Related Risk Factors Among Hemophilia and Thalassemia Patients in Iran | en |
| Type | Research Article | en |
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