Design of Intelligent Polymer of Gelatin- Poly N-isopropyla- crylamide under Gamma radiation for Cellular Applications
| Author | Saeed Heidari-Keshel |
| Author | Bita Soleimani |
| Author | Maryam Ebrahimi |
| Author | Asghar Ashrafi Hafez |
| Author | Razieh Fallahakbarpour |
| Author | Mohammad Khaledian |
| Author | Fatemeh Yousefi |
| Author | Maryam Rostampour Kakroudi |
| Author | Forough Fathi Arateh |
| Accessioned Date | 2024-04-09T01:32:24Z |
| Available Date | 2024-04-09T01:32:24Z |
| Issued Date | 2013-12-31 |
| Abstract | Thermo-sensitive polymers were prepared by graft copolymerization of gelatin with N-Isopropylacrylamide via gamma radiation. Characterization of polymers such as DSC analysis, swelling in different ratios and cell assays were investigated. DSC and solubility analysis showed gelatin and N-Isopropylacrylamide monomers were grafted via gamma radiation successfully. Results show swelling of samples increased as gelatin increased. Swelling ratio and curves results administrated hyd-ro-philicity / hydrophobicity of hydrogel that this property is due to presence of NIsopropylacrylamide in different temperatures. The polymer was tested for harvesting epithelial cells after carrying out cell culture at 37 °C and incubating the confluent cells at 10°C for spontaneous detachment of cell sheet from polymer surface without enzyme treatment. These unique properties of the hydrogel would make it a promising support for drug delivery systems and tissue regeneration. |
| DOI | https://doi.org/ |
| URI | https://repository.brieflands.com/handle/123456789/59666 |
| Keyword | Thermo- Sensitive Polymer |
| Keyword | Gelatin |
| Keyword | N-Isopropylacrylamide |
| Keyword | Gamma Radiation |
| Keyword | Epithelial Cell Sheet |
| Publisher | Brieflands |
| Title | Design of Intelligent Polymer of Gelatin- Poly N-isopropyla- crylamide under Gamma radiation for Cellular Applications |
| Type | Research Article |