Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice
| Author | Jamal Shams | en |
| Author | Hedayat Sahraei | en |
| Author | Zohreh Faghih-Monzavi | en |
| Author | Seyed Hossein Salimi | en |
| Author | Seyedeh Maedeh Fatemi | en |
| Author | Ali Pourmatabbed | en |
| Author | Hassan Ghoshooni | en |
| Author | Mohammad Kamalinejad | en |
| Issued Date | 2008-04-30 | en |
| Abstract | Previous studies have shown that the extract of Papaver rhoeas reduces morphine dependence, locomotor activity and reward. In present study, the effects of hydro-alcohol extract of Papaver Rhoeas on the tolerance to analgesic effects of morphine in mice have been investigated using tail flick method. Subcutaneous (s.c.) administration of morphine (1, 2, 5 and 10 mg/kg) induced analgesia. However, intrapretoneal administration of the hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg) had not an effects on analgesia. Reduction of analgesic in mice pretreated with morphine (50 mg/kg, twice daily; for 3 days), alone, indicated that tolerance has been developed. Hydro-alcohol extract of Papaver rhoeas (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of three daily doses of morphine, attenuated the morphine tolerance dose-independently,indicating that administration of the extract reduces morphine tolerance in mice. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.757 | en |
| URI | https://brieflands.com/journals/ijpr/articles/128583 | en |
| Keyword | Mice | en |
| Keyword | Tolerance | en |
| Keyword | analgesia | en |
| Keyword | morphine | en |
| Keyword | Papaver rhoeas | en |
| Publisher | Brieflands | en |
| Title | Effects of Papaver rhoeas Extract on the Tolerance Development to Analgesic Effects of Morphine in Mice | en |
| Type | Research Article | en |
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