An Unusual Case of Radiation-Induced Dermatofibrosarcoma Protuberans: A Rare Type of Soft Tissue Sarcoma
| Author | Maryam Kalantari Khandani | en |
| Author | Masoumeh Nouri | en |
| Author | Kimia Darafshi | en |
| Orcid | Maryam Kalantari Khandani [0009-0003-1740-1636] | en |
| Orcid | Masoumeh Nouri [0009-0000-2220-6876] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Introduction: Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive soft tissue sarcoma characterized by a low metastatic potential but a high local recurrence rate. It is typically managed with wide surgical excision, with adjuvant therapies considered in cases of inadequate margins or high-grade variants. Ionizing radiation is known to induce various malignant skin tumors, but radiation-induced DFSP is exceptionally rare, with only a few documented cases. This case report presents an unusual instance of radiation-induced DFSP, highlighting the challenges in the diagnosis and management of this rare complication following radiation therapy. The case underscores the importance of long-term surveillance in patients with a history of radiation exposure and the need for early recognition of secondary malignancies. Case Presentation: We reported a patient with an unusual DFSP in the breast, which was confirmed by immunohistochemistry (IHC). This tumor developed at the margins of the radiotherapy field 6 years after the patient underwent breast-conserving surgery and radiotherapy for breast cancer. Conclusions: This case highlights the potential for DFSP to arise in patients with a history of breast cancer treated with radiotherapy. Awareness of this possibility is crucial for timely diagnosis and management. Therefore, precise consideration is crucial when deciding regarding the adjuvant radiation therapy indications, treatment volume, and radiotherapy method, as although the likelihood of developing secondary cancer is very low, it is not zero. | en |
| DOI | https://doi.org/10.5812/ijcm-159886 | en |
| Keyword | Dermatofibrosarcoma Protuberans | en |
| Keyword | Breast Cancer | en |
| Keyword | Radiotherapy | en |
| Keyword | Case Report | en |
| Publisher | Brieflands | en |
| Title | An Unusual Case of Radiation-Induced Dermatofibrosarcoma Protuberans: A Rare Type of Soft Tissue Sarcoma | en |
| Type | Case Report | en |
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