Improved Ocular Bioavailability of Moxifloxacin HCl using PLGA Nanoparticles: Fabrication, Characterization, <i>In-vitro</i> and <i>In-vivo </i>Evaluation
| Author | Fahim Ullah Khan | en |
| Author | Fazli Nasir | en |
| Author | Zafar Iqbal | en |
| Author | Steven Neau | en |
| Author | Ismail Khan | en |
| Author | Mohammad Hassan | en |
| Author | Muhammad Iqbal | en |
| Author | Aman Ullah | en |
| Author | Sumaira Irum Khan | en |
| Author | Mirina Sakhi | en |
| Issued Date | 2021-07-31 | en |
| Abstract | Improving the bioavailability of a drug at the ocular surface presents a profound challenge. Due to ocular physiological barriers, conventional eye drops exhibit poor bioavailability of drugs. Sustained-release nanoparticles may improve the residence time and hence increase absorption of the drug from the corneal surface. The current study focuses on the development of a nanoparticle-based system for the ophthalmic sustained delivery of moxifloxacin, to enhance ocular retention and bioavailability of the drug. PLGA was used as the matrix-forming polymer in the nanoparticle formulation. Nanoparticles were manufactured using a double emulsion (w/o/w) solvent evaporation technique. The formulation was optimized based on physicochemical properties, including size, polydispersity index, and stability. Nanoparticles were also evaluated for in-vitro drug release and pharmacokinetic evaluation in a rabbit model. The optimized formulation exhibited a relatively high initial release rate for six hours followed by sustained release of a drug via diffusion. The in-vivo ocular tolerance studies confirmed that moxifloxacin-loaded PLGA nanoparticles were non-irritating to the eye. The pharmacokinetic studies revealed that the nanoparticles provided a high Cmax, AUC, MRT, and low clearance rate when compared to commercial eye drops. It can be concluded that such PLGA nanoparticles offer the potential for improved bioavailability of moxifloxacin HCl. | en |
| DOI | https://doi.org/10.22037/ijpr.2021.114478.15054 | en |
| Keyword | Polymeric nanoparticles | en |
| Keyword | Moxifloxacin hydrochloride | en |
| Keyword | Ocular bioavailability | en |
| Keyword | Pharmacokinetics | en |
| Keyword | Irritation | en |
| Publisher | Brieflands | en |
| Title | Improved Ocular Bioavailability of Moxifloxacin HCl using PLGA Nanoparticles: Fabrication, Characterization, <i>In-vitro</i> and <i>In-vivo </i>Evaluation | en |
| Type | Original Article | en |