Serotype Distribution of <i>Streptococcus pneumoniae</i> Carriage in Six-Month-Old Infants: A Cross-sectional Study During 2017-18, Tehran, Iran
| Author | Shirin Sayyahfar | en |
| Author | Abdoulreza Esteghamati | en |
| Author | Seyed Alireza Fahimzad | en |
| Author | Safura Hajisadeghi-Isfahani | en |
| Author | Ali Nazari-Alam | en |
| Author | Leila Azimi | en |
| Orcid | Abdoulreza Esteghamati [0000-0002-2276-7064] | en |
| Orcid | Seyed Alireza Fahimzad [0000-0001-6054-0656] | en |
| Orcid | Ali Nazari-Alam [0000-0003-4770-5836] | en |
| Orcid | Leila Azimi [0000-0002-7216-2530] | en |
| Issued Date | 2022-01-31 | en |
| Abstract | Background: Streptococcus pneumoniae is recognized as one of the main pathogens inducing several invasive and non-invasive infections in children. Objective: The present study aimed to evaluate the serotype distribution of S. pneumoniae in six–month–old carriers. Methods: This study encompassed 600 six-month-old healthy infants whose pharyngeal swap samples were collected and then cultured to isolate S. pneumoniae. Twenty- five different serotypes were defined on positive culture samples by multiplex PCR. Results: In this study, 13 cases (2.2%) were positive S. pneumonia. The most common isolated serotypes of S. pneumoniae were serotypes 23F (n = 6, 1%) and 3 (n = 3, 0.5%), respectively. Notably, the most frequent serotype in formula-fed infants (n = 300) was Serotype 23F (n = 5, 1.7%); however, Serotype 3 (n = 3, 1%) was the most frequent one in breastfed participants (n = 300). According to the findings, the overall coverage of PCV10, PCV13, and PPSV23 on the S. pneumoniae serotypes at the age of six months was 50%, 73%, and 85%, respectively. Conclusions: At this age, the type of feeding could not significantly affect the frequency rate of S. pneumoniae colonization, while the serotype distributions in the two breastfed and formula-fed groups were different. | en |
| DOI | https://doi.org/10.5812/pedinfect.112705 | en |
| Keyword | <i>Streptococcus pneumoniae</i> | en |
| Keyword | Colonization | en |
| Keyword | Infants | en |
| Keyword | Serotypes | en |
| Keyword | Vaccine | en |
| Publisher | Brieflands | en |
| Title | Serotype Distribution of <i>Streptococcus pneumoniae</i> Carriage in Six-Month-Old Infants: A Cross-sectional Study During 2017-18, Tehran, Iran | en |
| Type | Research Article | en |
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