Mutational Analysis of the PTEN/MMAC1 Tumor Suppressor Gene in Sporadic Glioblastoma Multiforme

Abstract

Background: In 1997 MMAC1 or the PTEN gene, was identified as a tumor suppressor gene on the long arm of chromosome 10.PTEN involves in the balance between proliferation, and differentiation, apoptosis and regulation of angiogenesis, and eventually mutation in this gene causes a strong potential for tumorigenesis cells. This study is the first report of the correlation between PTEN gene mutations with histological markers and the age of Glioblastoma patients with the purpose of using it to remove diagnostic ambiguities and identify the type of glioma.