Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from <i>Alnus japonica </i>Stem Bark
| Author | Sabrin R.M. Ibrahim | en |
| Author | Gamal A. Mohamed | en |
| Author | Amgad I. M. Khedr | en |
| Author | Bader M. Aljaeid | en |
| Issued Date | 2017-03-31 | en |
| Abstract | A new cyclic diarylheptanoid namely alnuheptanoid B (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)-S-myricanol (2), myricanone 5-O- -D-glucopyranoside (4), and (+)-S-myricanol 5-O- -D-glucopyranoside (5) were isolated from the EtOAc fraction of Alnus japonica Steud (family: Betulaceae) stem bark. Their structures were established by different spectroscopic analyses, as well as optical rotation measurement. Compounds 1, 2, 4, and 5 are isolated for the first time from A. japonica. The antioxidant and anti-inflammatory activities of compounds (1-5) were assessed using DPPH assay and carrageenin induced rat paw edema model, respectively. They displayed significant antioxidant activity in relation to propyl gallate (standard antioxidant) at concentration 50 µM. Compound 2 demonstrated anti-inflammatory effect at a dose 10 mg/kg compared with indomethacin (positive control). | en |
| DOI | https://doi.org/10.22037/ijpr.2017.1989 | en |
| Keyword | <i>Alnus japonica</i> | en |
| Keyword | Alnuheptanoid B | en |
| Keyword | Cyclic diarylheptanoid | en |
| Keyword | Antioxidant | en |
| Keyword | Anti-inflammatory | en |
| Publisher | Brieflands | en |
| Title | Anti-oxidant and Anti-Inflammatory Cyclic Diarylheptanoids from <i>Alnus japonica </i>Stem Bark | en |
| Type | Original Article | en |
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