Cell Survival Entropy and Cellular Resistance Activation Dose: Effect of Calprotectin on Gastric Adenocarcinoma Cell Line

Abstract

Background: The survival curves generally have been used for analysis of cell survival under stress conditions. They depict the relationship between the fraction of cells retaining their reproductive integrity and the absorbed dose. The median lethal dose, Lethal Concentration, 50% (LC50) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after specified test duration. LC50 frequently are used as a general indicator of a substance's acute toxicity. In this study a novel thermodynamic model is introduced to examine cell survival under stress condition. The survival function describes the surviving fraction of cell survival in different doses and contains information about cell survival. However, for interpretation of cells behavior under stress condition, thermodynamic formalism is utilized.