In Vitro Anti-Candida Activity of the Hydroalcoholic Extracts of Heracleum persicum Fruit Against Phatogenic Candida Species
| Author | Batool Sadeghi Nejad |
| Author | Mahsa Rajabi |
| Author | Ali Zarei Mamoudabadi |
| Author | Majid Zarrin |
| Issued Date | 2014-01-01 |
| Abstract | Background:: Nowadays Candida albicans has become resistant to the toxic and expensive commercial anti-Candida drugs. Therefore, investigation for new anti-fungal agents is necessary. Objectives:: The purpose of this survey was to investigate the in vitro anti-Candida activity of the hydroalcoholic extracts of Heracleum persicum fruit. Materials and Methods:: The plant ingredients were extracted using 80% ethanol and the extract was screened against 46 isolated pathogenic Candida species such as C. albicans, C. glabrata and C. tropicalis by agar well diffusion method. Results:: The minimum inhibitory concentration (MIC) values at 24 and 48 hours were 0.625 - 20 µg/µL for C. albicans, 0.625 - 40 µg/µL for C. glabrata, and 5.0 - 20 µg/µL for C. tropicalis. Conclusions:: The results of this survey confirmed that tested plant extract had a potential anti-Candida activity. Hence, it is suggested to isolate and identify its active compounds in future. |
| DOI | https://doi.org/10.5812/jjm.8703 |
| Keyword | Heracleum |
| Keyword | Extract |
| Keyword | Candida |
| Publisher | Brieflands |
| Title | In Vitro Anti-Candida Activity of the Hydroalcoholic Extracts of Heracleum persicum Fruit Against Phatogenic Candida Species |
| Type | Research Article |
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