Effect of a Combination of Omeprazole Plus Sustained Release Baclofen Versus Omeprazole Alone on Symptoms of Patients with Gastroesophageal Reflux Disease (GERD)
| Author | Mohammad Abbasinazari | en |
| Author | Yunes Panahi | en |
| Author | Seyed Alireza Mortazavi | en |
| Author | Fanak Fahimi | en |
| Author | Ghasem Valizadegan | en |
| Author | Reza Mohtashami | en |
| Author | Mohammad Amin Pourhoseingholi | en |
| Author | Kambiz Shirvani Bakhtiari | en |
| Issued Date | 2014-10-31 | en |
| Abstract | Previous studies have reported the efficacy of baclofen in the treatment of Gastroesophageal Reflux Diseases (GERD). The objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained Release baclofen (SR baclofen) vs. omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of GERD. A prospective, double blind, placebo controlled trial included 60 patients with diagnosis of GERD have been done. Patients were randomly selected to receive either SR baclofen or a placebo in addition to omeprazole 20 mg/d for a period of 2 weeks. Patients were questioned regarding heartburn, regurgitation, chest pain and hoarseness at the base line and after 2 weeks. All patients tolerated the medications and no patients failed to complete the study due to adverse drug reactions. A total of 53 patients completed the study, 25 in SR baclofen and 28 in placebo group. After 2 weeks, 1 patient (4%) in SR baclofen group reported heartburn and regurgitation. However 13(46.4%) and 15 (53.6%) of patients in the placebo group had heartburn and regurgitation respectively. The analysis of the data shows that there is a significant difference between the two groups in heartburn and regurgitation (p < 0.0001, p < 0.0001 respectively). Statistical analysis revealed a significant difference in two groups regarding total GERD score (p | en |
| DOI | https://doi.org/10.22037/ijpr.2014.1593 | en |
| Keyword | Baclofen | en |
| Keyword | Omeprazole | en |
| Keyword | GERD | en |
| Keyword | Sustained release | en |
| Publisher | Brieflands | en |
| Title | Effect of a Combination of Omeprazole Plus Sustained Release Baclofen Versus Omeprazole Alone on Symptoms of Patients with Gastroesophageal Reflux Disease (GERD) | en |
| Type | Original Article | en |
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