Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer
| Author | Vegesna Naga Sravan Kumar Varma | en |
| Author | Hosakote Gurumalappa Shivakumar | en |
| Author | Veerna Balamuralidhara | en |
| Author | Manne Navya | en |
| Author | Umme Hani | en |
| Issued Date | 2016-01-31 | en |
| Abstract | The aim of the research work was to chemically modify guargum (GG) as a pH sensitive co-polymer and formulating intestinal targeting ESO nanoparticles (NPs) using the synthesized co-polymer. Poly acrylamide-grafted-guar gum (PAAm-g-GG) co-polymer was synthesized by free radical polymerization. Chemical modification of PAAm-g-GG by alkaline hydrolysis results in formation of a pH-sensitive co-polymer. The effect of GG and acryl amide (AAm) on grafting was studied. Esomeprazole magnesium (ESO) loaded pH sensitive NPs were prepared by nano-emulsification polymer crosslinking method and characterized. Sixteen formulations were prepared and the concentration of process variables wasvaried to obtain nanoparticles of 200-600 nm. The NPs were found to be homogenous in size distribution. The encapsulation efficiency and drug loading ranged from 33.2% to 50.1% and 12.2% to 17.2% respectively. Particle size, encapsulation efficiency and drug loading increasedalong with co-polymer concentration. In-vitro release studies at pH 1.2 for 2 h, followed by pH 6.8 showed that environment pH significantly affected the drug release. SEM has shown that NPsare spherical with smooth surface. The pH sensitive PAAm-g-GGNPs resisted the initial release of the drug from the drug loaded NPs in acidic pH and delayed the release process to a longer period in alkaline environment. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1771 | en |
| Keyword | pH sensitive nanoparticles | en |
| Keyword | PAAm-g-GG | en |
| Keyword | intestinal drug delivery | en |
| Keyword | guar gum | en |
| Keyword | Esomeprazole | en |
| Publisher | Brieflands | en |
| Title | Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer | en |
| Type | Original Article | en |