Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian Population
| Author | Zahra Heidari | en |
| Author | Bita Moudi | en |
| Author | Hamidreza Mahmoudzadeh Sagheb | en |
| Author | Mehrnoosh Moudi | en |
| Orcid | Bita Moudi [0000-0001-6893-625X] | en |
| Issued Date | 2016-11-01 | en |
| Abstract | Background: The host genetic background regulates the natural history of chronic hepatitis B virus (HBV) infection. Objectives: The aim of this study was to investigate the association between TNF-α gene polymorphism in the promoter region and susceptibility to chronic hepatitis B virus infection. Methods: Four polymorphisms of TNF-α gene including -238 A/G, -308 A/G, -857 C/T, and -863 A/C were analyzed by PCR-RFLP in 100 chronic HBV infected patients (HBV group), 40 spontaneously recovered HBV subjects (SR group), and 100 healthy controls (C group). Also, serum levels of protein were monitored. Results: The study showed that the existence of -308 G, -857 C, and -863 A alleles significantly increased susceptibility to chronic HBV infection. In addition, GGCA haplotype had a higher frequency in HBV patients than C and SR groups that might be related to the natural history of the infection. Chronic HBV patients with -308 GG, -857 CC, and -863 AA genotypes had lower serum levels of TNF-α compared to those with other genotypes. Conclusions: The results indicated that there was a positive association between susceptibility to chronic HBV infection and TNF-α polymorphism. In addition, HBV patients carrying -308 GG, -857 CC, and -863 AA genotypes with lower serum levels of TNF-α had an increased risk of infection. | en |
| DOI | https://doi.org/10.5812/hepatmon.41984 | en |
| Keyword | Tumor Necrosis Factor-a | en |
| Keyword | Chronic Hepatitis B Virus | en |
| Keyword | Gene | en |
| Keyword | Polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian Population | en |
| Type | Research Article | en |