Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial
| Author | Hosein Eslami | en |
| Author | Zahra Jamali | en |
| Author | Hossein Babaei | en |
| Author | Vahid Fakhrzadeh | en |
| Author | Javad Ahamdi | en |
| Author | Fatemeh Tavakoli | en |
| Orcid | Hosein Eslami [0000-0002-0050-5872] | en |
| Orcid | Fatemeh Tavakoli [0000-0002-3297-5465] | en |
| Issued Date | 2022-11-30 | en |
| Abstract | Background: Mucositis is one of the most important complications of radiotherapy. Some factors such as type of treatment and degree of patient sensitivity affect mucositis occurrence. Objective: This research was implemented to evaluate the effect of grape seed extract on radiation-induced mucositis. Methods: This research is a double-blinded randomized clinical trial implemented on 78 patients undergoing head and neck radiotherapy in the oncology ward of Imam Reza Hospital of Tabriz. The patients were randomly divided into 2 groups, the intervention, and the control group. Each group included 39 patients. The intervention group used 2% grape seed extract mouthwashes and the control group used placebo mouthwashes. The mouthwashes were used 3 times a day for 2 weeks. For statistical analysis of collected data, SPSS 20 software was applied. Results: The results showed that according to the Friedman test, on the 10th and 14th days, mucositis grade and incidence had a significant difference between the intervention and control groups. Conclusions: The findings indicated that grape seed extract mouthwash in preventing radiation-induced mucositis was more effective than a placebo. Thus, this agent can be recommended as an appropriate medication to eliminate oral mucositis symptoms. | en |
| DOI | https://doi.org/10.5812/ijcm-130603 | en |
| Keyword | Cancer | en |
| Keyword | Grape Seed Extract | en |
| Keyword | Mucositis | en |
| Keyword | Radiotherapy | en |
| Publisher | Brieflands | en |
| Title | Evaluation of the Effect of Grape Seed Extract (GSE) on Oral Mucositis in Patients with Head and Neck Radiotherapy History- A Randomized Clinical Trial | en |
| Type | Research Article | en |
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