Invasive Growth Hormone Producing Pituitary Adenoma With Lymphocytic Infiltration: A Case Report and Literature Review
| Author | Farahnaz Bidari-Zerehpoosh | en |
| Author | Gieve Sharifi | en |
| Author | Kambiz Novin | en |
| Author | Nafiseh Mortazavi | en |
| Orcid | Kambiz Novin [0000-0001-7524-5887] | en |
| Orcid | Nafiseh Mortazavi [0000-0002-4432-8783] | en |
| Issued Date | 2015-12-28 | en |
| Abstract | Introduction:: We have presented a rare case of growth hormone (GH) producing pituitary adenoma with lymphocytic infiltration and brain parenchyma invasion. Case Presentation:: A 37-year-old woman has presented with complaints of headache, amenorrhea and acromegalic features. Her laboratory studies showed markedly elevated levels of Insulin-like Growth Factor 1 (IGF-1), and low levels of follicle stimulating hormone and luteinizing hormone. Computerized tomography has revealed a pituitary mass without extra-sellar extension. The tumor has completely excised via trans-nasal endoscopic approach. Histologically, the tumor has diagnosed as a pituitary adenoma with GH positive cells. The serum IGF1 levels have gradually decreased to the normal range and the patient was symptom free for three and a half years when she has returned with complaint of visual impairment. The brain MRI that time has shown a supra-sellar mass growing independently into the remaining sellar part. Subsequently, surgical operation has performed via trans-nasal endoscopic approach. Histopathological and immunohistochemistry examination have revealed a rare case of growth hormone producing pituitary adenoma with brain invasion and lymphocytic infiltration. Conclusions:: The aim of this publication was to present a rare case of growth hormone producing pituitary adenoma with brain invasion and lymphocytic infiltration. | en |
| DOI | https://doi.org/10.17795/ijcp-3504 | en |
| Keyword | Pituitary Adenoma | en |
| Keyword | Lymphocytic Infiltration | en |
| Keyword | Growth Hormone Producing | en |
| Keyword | Supra-Sellar | en |
| Publisher | Brieflands | en |
| Title | Invasive Growth Hormone Producing Pituitary Adenoma With Lymphocytic Infiltration: A Case Report and Literature Review | en |
| Type | Case Report | en |