REVIEW ON T-2 TOXIN

Abstract

T-2 toxin is a member of the fungal metabolites known as trichothecene mycotoxin. The major attribute of T-2 toxin is that it inhibit protein synthesis which is followed by a secondary disruption of DNA and RNA synthesis. T-2 toxin affects the actively dividing cells such as those lining the gastrointestinal tract, skin, lymphoid and erythroid cells. It can decrease antibody levels, immunoglobolines and certain other humoral factors. In addition, in this review article acute and chronic effects on health, toxicokinetics, regulatory matters related to its use as a potential warfare and treatment strategies that may be undertaken will be briefly covered.