Characterization of Emulsification Profiles of Developed Lipid Formulation for the Oral Delivery of Poorly Water-Soluble Drugs
| Author | Naser Hasan | en |
| Author | Raniya S Bakhsh | en |
| Author | Abdullah H Shabakh | en |
| Author | Dina H. Aldhahri | en |
| Author | Mohammed Y. Dakkak | en |
| Author | Manal S. AL-Harbi | en |
| Author | Raneem A. Alobydan | en |
| Accessioned Date | 2026-06-14T10:43:04Z | |
| Issued Date | 2026-12-31 | en |
| Abstract | Background: The design of robust self-micro-emulsifying lipid formulations to enhance the bioavailability of poorly water-soluble drugs requires studying the interaction between the type of oil, co-surfactant, and type of surfactant. These blended constituents control the hydrophilicity of the lipid vehicle, drug solubility in the lipid matrix, and the physicochemical state of the drug after dispersion. Objectives: Archetypical lipid class systems were formulated, and the resultant aqueous dispersions were characterized. Ternary miscibility diagrams and physicochemical properties of the resultant dispersions with and without model drug were analyzed. Methods: Various lipid mixtures were blended by varying key elements in the vehicle composite, which include the type of oil, co-surfactant, and surfactant. Miscibility and equilibrium aqueous dispersion profiles were mapped out to screen for microemulsions. Solubility profiles of various drugs were studied in varying lipid compositions. Results: At minimal ratios of {soybean/cremophore} (1:9) or {span 80/tween 80} (2:8), only 10% w/w of tween 20 is required to obtain microemulsion dispersions. Whereas, in the case of glycerox/tween 20/cremophor RH40, a complete region of clear emulsions was obtained at all ratios. Conclusions: Robust microemulsion lipid systems are fabricated to mimic the absorption of poorly water-soluble compounds with minimal tendency for drug recrystallization in situ after aqueous dispersion. | en |
| DOI | https://doi.org/10.5812/jrps-168970 | en |
| URI | https://repository.brieflands.com/handle/123456789/67712 | |
| Keyword | Lercanidipine HCl | en |
| Keyword | Biorelevant Media | en |
| Keyword | SEDDS | en |
| Keyword | Long-Chain Glycerides | en |
| Keyword | Medium-chain Glycerides | en |
| Publisher | Brieflands | en |
| Title | Characterization of Emulsification Profiles of Developed Lipid Formulation for the Oral Delivery of Poorly Water-Soluble Drugs | en |
| Type | Research Article | en |