Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension
| Author | Ali Akbar Nekooeian | en |
| Author | Azadeh Khalili | en |
| Author | Katayoun Javidnia | en |
| Author | Ahmad Reza Mehdipour | en |
| Author | Ramin Miri | en |
| Issued Date | 2009-07-31 | en |
| Abstract | Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. In this study, antihypertensive effects of 5 newly synthesized derivatives of DHP was examined the in rat model of two-kidney, one-clip renal hypertension. The results showed that those compounds containing two nitroxy groups had less decreasing effect on MAP (Men Arterial Pressure) compared to those having one nitroxy group in 5 position. On the other hand, conformational analysis indicated that in two compounds with two chains (A and E), a great steric hindrance existed; therefore, steric hindrance is the most important factor for interaction of compounds with their receptors. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.810 | en |
| Keyword | MAP | en |
| Keyword | one-clip hypertension | en |
| Keyword | two-kidney | en |
| Keyword | 1,4-Dihydropyridines | en |
| Publisher | Brieflands | en |
| Title | Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension | en |
| Type | Research Article | en |
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