Incidence, Clinicomicrobiological Characteristics, Risk Factors, and Treatment Outcomes of Bacterial Infections Following Liver Transplantation in Pediatrics: A Retrospective Cohort Study
| Author | Afsaneh Vazin | en |
| Author | Reza Shahriarirad | en |
| Author | Nazanin Azadeh | en |
| Author | Nahid Parandavar | en |
| Author | Kourosh Kazemi | en |
| Author | Mojtaba Shafiekhani | en |
| Orcid | Reza Shahriarirad [0000-0001-5454-495X] | en |
| Issued Date | 2022-10-31 | en |
| Abstract | Background: Liver transplantation (LT) is the definitive treatment for patients with advanced liver failure. Bacterial infections are common consequences of organ transplantation resulting from immune suppression and prolonged hospitalization. Methods: This retrospective cohort study examined the records of all liver transplant pediatrics under 18 years of age in Abu-Ali Sina hospital, Shiraz, Fars province, Iran, from April 2019 to February 2020. Demographic, laboratory, and clinical data were extracted along with the administered therapeutic approach for the patient. Results: Of 80 enrolled patients, 52 were male, and 28 were female, with a median age of 60 months. An incidence of 67.9% of bacterial infections was recorded. Gram-negative and Gram-positive pathogens accounted for 64.06% and 35.93% of infections, respectively. Surgical site infections were the most common ones. The length of ICU stay, hospitalization, mechanical ventilation duration, and re-hospitalization were significantly higher in the infected group than in non-infected pediatrics (P-value < 0.05). Multivariate regression analysis showed that the only risk factor for bacterial infections after LT was the length of ICU stay. The mortality rate was 22%, which was significantly higher among the infection group (P = 0.008). Conclusions: A high rate of bacterial infections and an increasing prevalence of nosocomial and antibiotic-resistant pathogens were detected in the early period after LT. | en |
| DOI | https://doi.org/10.5812/pedinfect-118809 | en |
| Keyword | Liver Transplantation | en |
| Keyword | Bacterial Infections | en |
| Keyword | Hospital-Acquired Infection | en |
| Keyword | Antibiotic Resistance | en |
| Publisher | Brieflands | en |
| Title | Incidence, Clinicomicrobiological Characteristics, Risk Factors, and Treatment Outcomes of Bacterial Infections Following Liver Transplantation in Pediatrics: A Retrospective Cohort Study | en |
| Type | Research Article | en |
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