Simultaneous Spectrophotometric Determination of Amlodipine and Metoprolol by Principal Component Regression Multivariate Calibration and Comparison with HPLC
| Author | Mohsen Shahlaei | en |
| Author | Farshid Hassanzadeh | en |
| Author | Jaber Emami | en |
| Author | Ehsan Sohrabi | en |
| Author | Lotfollah Saghaie | en |
| Issued Date | 2013-12-31 | en |
| Abstract | Multi-drug therapy in high blood pressure is appreciated to achieve a normal blood pressure. A simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (Amd) and metoprolol (Met) in pharmaceutical preparations. Calibration matrix contains 3.402 μgml-1 to 170.130 μg ml-1 amlodipine and 13.7 μg ml-1 to 68.5 μgml-1 metoprolol. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of amlodipine and metoprolol in different pharmaceutical preparations. | en |
| DOI | https://doi.org/ | en |
| Keyword | Amlodipine | en |
| Keyword | Metoprolol | en |
| Keyword | Multivariate calibration | en |
| Keyword | Spectrophotometic Methods | en |
| Publisher | Brieflands | en |
| Title | Simultaneous Spectrophotometric Determination of Amlodipine and Metoprolol by Principal Component Regression Multivariate Calibration and Comparison with HPLC | en |
| Type | Research Article | en |