A Comprehensive Long-Term Prognosis of Chronic Hepatitis C Patients With Antiviral Therapy: A Meta-Analysis of Studies From 2008 to 2014
| Author | Ya Wen | en |
| Author | Yi Xiang Zheng | en |
| Author | De Ming Tan | en |
| Issued Date | 2015-05-01 | en |
| Abstract | Context: Attaining a sustained virological response with antiviral therapy is a sign of clinical cure for chronic hepatitis C patients. The aim of this meta-analysis was to evaluate the long-term efficiency and outcome of antiviral therapy in patients with hepatitis C who attained a sustained virological response. Evidence Acquisition: A literature search was performed on published articles between January 2008 and February 2014. Patients with Hepatitis C who received interferon with or without ribavirin therapy were enrolled. Relative risks were estimated using either fixed or random effect models. Results: Patients who attained sustained virological response had a less risk (85%) for all-cause mortality and about 63% reduced risk of hepatocellular carcinoma incidence than those who did not achieve sustained virological response. Based on deeply analysis, the stage of liver fibrosis was a risk factor at baseline for the incidence of hepatocellular carcinoma. Conclusions: Sustained virological response can reduce all-cause mortality and the incidence of hepatocellular carcinoma of patients with hepatitis C. Advanced liver fibrosis is still a risk factor for the incidence of hepatocellular carcinoma, in spite of hepatitis C patients attained a sustained virological response. | en |
| DOI | https://doi.org/10.5812/hepatmon.15(5)2015.27181 | en |
| Keyword | Chronic Hepatitis C | en |
| Keyword | Meta-Analysis | en |
| Keyword | Antiviral Therapy | en |
| Publisher | Brieflands | en |
| Title | A Comprehensive Long-Term Prognosis of Chronic Hepatitis C Patients With Antiviral Therapy: A Meta-Analysis of Studies From 2008 to 2014 | en |
| Type | Review Article | en |
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