The Role of IL-6 for Predicting Neonatal Sepsis: A Systematic Review and Meta-Analysis
| Author | Gholamreza Roshandel | en |
| Author | Ali Ahani | en |
| Author | Arezou Mirfazeli | en |
| Author | Lobat Shahkar | en |
| Author | Abbasali Keshtkar | en |
| Issued Date | 2011-12-31 | en |
| Abstract | Objective: Neonatal sepsis (NS) is a common and life-threatening disorder in infants. Previous studies showed that interleukin-6 (IL-6) may be a valid non-invasive and rapid method for diagnosis of NS. We conducted this review to assess the validity of IL-6 for predicting NS. Methods: This was a systematic review with meta-analysis. Embase, Medline and Web of Science databases were searched between January 1990 and December 2009. The search terms used were “cytokine”, “neonate”, “sepsis” and “interleukin-6". We used standard methods recommended for meta analyses of diagnostic test evaluations. The analysis was based on a summary ROC (SROC) curve. Meta-regression analysis was used to assess the effects of some confounding factors on the results of meta-analysis. Potential presence of publication bias was tested using funnel plots and the Egger test. Findings: Meta-analysis was performed on 13 publications including 353 infants with sepsis and 691 control infants. The pooled sensitivity and specificity of IL-6 was 0.79 and 0.84, respectively. The maximum joint sensitivity and specificity (i.e., the Q value) in SROC curve was 0.82 and the area under curve (AUC) was 0.89 (95% CI: 0.84-0.94). Meta-regression analysis showed that the diagnostic accuracy of IL-6 was not affected by confounding variables. The evaluation of publication bias showed that the Egger test was not significant (P=0.07). Conclusion: IL-6 seems to be a valid marker for predicting NS. It may be considered for early diagnosis of sepsis in neonatal care units. | en |
| DOI | https://doi.org/ | en |
| Keyword | Interlukin-6 | en |
| Keyword | Cytokines | en |
| Keyword | Sepsis | en |
| Keyword | Neonate | en |
| Keyword | Meta-analysis | en |
| Publisher | Brieflands | en |
| Title | The Role of IL-6 for Predicting Neonatal Sepsis: A Systematic Review and Meta-Analysis | en |
| Type | Review Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 411-417.pdf
- Size:
- 427.31 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF