Anti-angiogenic/inflammatory Behavior of Mushroom Ganoderma Lucidum Extract could be Effective for Treatment of Corneal Neovascularization: A Hypothesis

Abstract

Neovascularization of the normally avascular cornea was associated with a notable increase in the expression of the major pro-angiogenic factors, inflammatory cytokines and proteases. The data supporting a causal role for vascular endothelial growth factor (VEGF), inflammatory cytokines and matrix metalloproteinase (MMPs) are extensive. Anti-angiogenic/anti-inflammatory therapy is considered as a possible tool for controlling corneal neovascularization. Mushroom Ganoderma Lucidum extracts containing materials that significantly reduced the number of newly formed vessels and expression of inflammatory cytokines and angiogenic factors production from various cells. This study aimed to elucidate anti-angiogenic activity of Ganoderma Lucidum extract for inhibiting corneal neovascularization and restoration of corneal neovascularization and restoration.