The Troponin-I Release in Patients with Left-Sided Early-Stage Breast Cancer Undergoing Adjuvant Whole Breast Radiotherapy: An Iranian Experience
| Author | Amir Shahram Yousefi Kashi | en |
| Author | Maryam Karimi | en |
| Author | Afshin Rakhsha | en |
| Author | Amir Javadzadegan | en |
| Author | Farzad Taghizadeh-Hesary | en |
| Orcid | Amir Shahram Yousefi Kashi [0000-0002-0787-2480] | en |
| Orcid | Afshin Rakhsha [0000-0001-9601-7074] | en |
| Orcid | Farzad Taghizadeh-Hesary [0000-0002-6195-2203] | en |
| Issued Date | 2020-10-31 | en |
| Abstract | Background: Breast cancer is the most frequent cancer among women. In line with the survival improvement of patients with cancer, the issue of treatment-induced toxicities becomes more important. Objectives: This study aimed at evaluating acute radiation-induced cardiac damage. Methods: Between 2016 and 2019, women with histologically-confirmed early-stage left-sided breast cancer or ductal carcinoma in-situ (DCIS) without prior chemotherapy, who were candidates for adjuvant whole breast radiotherapy, entered the study. The radiation-induced cardiotoxicity was assessed, using a rise in high-sensitivity cardiac troponin I (hscTnI) over the radiotherapy. Likewise, the association between the percentage of heart receiving at least 25Gy (V25Gy) and the rise in hscTnI was evaluated as the secondary endpoint. Results: A total of 22 women were included in this study. Mean ± standard deviation (SD) hscTnI for the whole study population was 12 ± 2 ng/L before and 15 ± 2 ng/L after radiotherapy. The median (interquartile range [IQR]) V25Gy was 8.05% (6.95% - 8.95%). The difference between hscTnI levels before and after radiotherapy was significant (P = 0.001). There was no correlation between V25Gy and the rise in hscTnI (P = 0.18). Conclusions: hscTnI is a sensitive marker to detect early radiation-induced cardiotoxicity. There is no association between V25Gy and the rise in hscTnI over radiotherapy. | en |
| DOI | https://doi.org/10.5812/ijcm.107043 | en |
| Keyword | Radiotherapy | en |
| Keyword | Breast Neoplasms | en |
| Keyword | Cardiotoxicity | en |
| Keyword | troponin | en |
| Publisher | Brieflands | en |
| Title | The Troponin-I Release in Patients with Left-Sided Early-Stage Breast Cancer Undergoing Adjuvant Whole Breast Radiotherapy: An Iranian Experience | en |
| Type | Research Article | en |
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