Metastatic Breast Signet-Ring Cell Carcinoma from a Colonic Primary: Review of a Rare Case Report
| Author | Ghazaleh Shaker | en |
| Author | Hayedeh Haeri | en |
| Author | Behnaz Jahanbin | en |
| Orcid | Ghazaleh Shaker [0000-0003-2374-7855] | en |
| Orcid | Hayedeh Haeri [0000-0002-2762-5591] | en |
| Orcid | Behnaz Jahanbin [0000-0003-2374-7855] | en |
| Issued Date | 2021-12-31 | en |
| Abstract | Introduction: Colonic signet-ring cell carcinoma is a distinctive rare subtype of adenocarcinoma with a predilection for early metastasis. Among the rare extramammary metastatic adenocarcinomas to the breast, colonic signet-ring cell carcinomas constitute a small percentage. The distinction of a primary from a secondary breast signet-ring cell carcinoma is indispensable since it may result in different therapeutic approaches. Here we presented a rare case of metastatic breast signet-ring cell carcinoma from a rectal origin and review its distinctive histopathologic features. Case Presentation: A 37-year-old woman presented with a breast mass 3 months after undergoing low anterior resection surgery to remove a rectal mass, diagnosed as signet-ring cell carcinoma. Histopathologic examination of the core needle breast mass biopsy revealed tumor cells with signet-ring cell cytomorphology. The performed immunohistochemistry confirmed carcinoma of colonic origin. Conclusions: Colorectal signet-ring cell carcinoma is a rare and aggressive tumor. Its metastatic spread is most seen in the intra-abdominal area, with seldom reported cases of breast metastasis. Histologically, it can mimic a primary breast carcinoma, especially if no prior history of colonic origin exists. Accurate diagnosis is important since these two entities carry different therapeutic management. Proper immunophenotyping, obtaining a thorough clinical history and imaging studies facilitate a correct diagnosis. | en |
| DOI | https://doi.org/10.5812/ijcm.118117 | en |
| Keyword | Signet-Ring Cell Carcinoma | en |
| Keyword | Colon | en |
| Keyword | Breast | en |
| Keyword | Metastasis | en |
| Publisher | Brieflands | en |
| Title | Metastatic Breast Signet-Ring Cell Carcinoma from a Colonic Primary: Review of a Rare Case Report | en |
| Type | Case Report | en |