The Photothermal Effect of Targeted Methotrexate-Functionalized Multi-Walled Carbon Nanotubes on MCF7 Cells
| Author | Ali Karimi | en |
| Author | Mohammad Erfan | en |
| Author | Seyed Alireza Mortazavi | en |
| Author | Fatemeh Ghorbani-Bidkorbeh | en |
| Author | Behnaz Landi | en |
| Author | Farzad Kobarfard | en |
| Author | Farshad H. Shirazi | en |
| Issued Date | 2019-12-31 | en |
| Abstract | Our goal is to reduce the release rate of methotrexate (MTX) and increase cell death efficiency.Carboxylated multi-walled carbon nanotubes (MWCNT-COOH) were functionalized with MTX as a cytotoxic agent, FA as a targeting moiety and polyethylene amine (PEI) as a hydrophilic agent. Ultimately, MWCNT-MTX and MWCNT-MTX-PEI-FA were synthesized. Methotrexate release studies were conducted in PBS and cytotoxic studies were carried out by means of the MTT tassay. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.14484.12423 | en |
| Keyword | Multi-walled carbon nanotubes | en |
| Keyword | Photothermal | en |
| Keyword | Folic acid | en |
| Keyword | Methotrexate | en |
| Keyword | Polyethylenimine | en |
| Keyword | Targeting effect; Cancer cell | en |
| Publisher | Brieflands | en |
| Title | The Photothermal Effect of Targeted Methotrexate-Functionalized Multi-Walled Carbon Nanotubes on MCF7 Cells | en |
| Type | Original Article | en |
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