Preparation, Characterization and Evaluation of Drug Release Properties of Simvastatin-loaded PLGA Microspheres
| Author | Reza Masaeli | en |
| Author | Tahereh S. Jafarzadeh Kashi | en |
| Author | Rassoul Dinarvand | en |
| Author | Mohammadreza Tahriri | en |
| Author | Vahid Rakhshan | en |
| Author | Mehdi Esfandyari-Manesh | en |
| Issued Date | 2016-03-31 | en |
| Abstract | Microspheres formulated from poly (D, L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres were then frozen to −80 °C, they were freeze dried for 24 h. Characterization of SIM-loaded PLGA microspheres was evaluated by X-ray diffraction analysis, Fourier transform infrared spectroscopy analysis, and scanning electron microscopy (SEM). Drug release potential was evaluated by UV-spectrophotometry. The experimental results revealed that SIM-loaded PLGA microspheres can be successfully obtained through solvent evaporation method with appropriate morphologic characteristics and high encapsulation efficiency. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1821 | en |
| Keyword | Drug-delivery systems | en |
| Keyword | Simvastatin | en |
| Keyword | Poly (D | en |
| Keyword | L-lactic-co-glycolide) (PLGA) | en |
| Keyword | Microspheres | en |
| Keyword | Controlled release | en |
| Publisher | Brieflands | en |
| Title | Preparation, Characterization and Evaluation of Drug Release Properties of Simvastatin-loaded PLGA Microspheres | en |
| Type | Original Article | en |