Modulatory Effects of Rosemary Leaves Aqueous Extract on Doxorubicin‐Induced Histological Lesions, Apoptosis and Oxidative Stress in Mice

Abstract

Background: Doxorubicin is used in treatment of many solid malignancies and lymphomas with poorly understood mechanism underlying tissue injury. Rosemary leaves or extracts were found to contain high antioxidant activity almost equivalent to BHA (Butylated Hydroxy Anesole) and BHT (Butylated Hydroxy Toluene). Thus, the possibility of aqueous rosemary leaves extract (RE) to ameliorate doxorubicininduced histological lesions, apoptosis and oxidative stress in male mice tissues was tested.