Comparison of Therapeutic Response of Keloids to Cryotherapy Plus Intralesional Triamcinolone Acetonide or Verapamil Hydrochloride
| Author | Parvin Jannati | en |
| Author | Saeed Aref | en |
| Author | Ahmad Amin Jannati | en |
| Author | Faezeh Jannati | en |
| Author | Hamideh Moravvej | en |
| Issued Date | 2015-03-31 | en |
| Abstract | Background: A keloid is dysregulated fibroproliferative scar tissue in response to skin injuries, which extends beyond the wound margin. Since it has a poor response to treatment, variable therapies are used. Current therapies of keloid include intralesional corticosteroid injection, cryotherapy and various laser therapies, silicone gel sheets (pressure therapy), interferon-α-2b, 5-fluoruracil or bleomycine administration, excision followed by low dose radiation or topical imiquimod. Objectives: The aim of this study was to compare the efficacy and safety of “intralesional triamcinolone with cryotherapy” and “Intralesional verapamil with cryotherapy”. Patients and Methods: Eighty patients (42 females and 38 males, aged 11 - 40 years) were allocated to receive one of the four treatment methods. Group 1: Intralesional triamcinolone with cryotherapy. Group 2: Intralesional verapamil with cryotherapy. Group 3: Intralesional verapamil. Group 4: Cryotherapy. Improvement of healing was measured using modified Vancouver scar scale and centimeter scale. Results: There was a real faster response in the first group; while groups 3 and 4 had the slowest responses to treatment. Rates of responsiveness seemed to have no significant difference between the groups, but side effects were significantly much frequent in the first group. Conclusions: Intralesional triamcinolone acetonide with cryotherapy showed the most efficacies with more adverse effects, but intralesional verapamil with cryotherapy showed good efficacy with less adverse effects. Hence, it is a suitable alternative in the treatment of keloids. | en |
| DOI | https://doi.org/10.17795/jssc2928 | en |
| Keyword | Keloid | en |
| Keyword | Cryotherapy | en |
| Keyword | Triamcinolone Acetonide | en |
| Keyword | Verapamil | en |
| Publisher | Brieflands | en |
| Title | Comparison of Therapeutic Response of Keloids to Cryotherapy Plus Intralesional Triamcinolone Acetonide or Verapamil Hydrochloride | en |
| Type | Research Article | en |
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