Effect of Fluvoxamine on Carrageenan-Induced Paw Edema in Rats Evaluation of the Action Sites
| Author | Valiollah Hajhashemi | en |
| Author | Hossein Sadeghi | en |
| Author | Mohsen Minaiyan | en |
| Author | Ahmad Movahedian | en |
| Author | Ardeshir Talebi | en |
| Issued Date | 2011-07-31 | en |
| Abstract | The present study was designed to explore the anti-inflammatory effect of fluvoxamine, as a selective serotonin reuptake inhibitor (SSRI) anti-depressant, on carrageenan-induced paw edema in more details. At first, fluvoxamine was administered intra-peritoneally (2.5, 12.5, 25 and 50 mg Kg-1) 30 min before the subplantar injection of carrageenan. Fluvoxamine was also injected intra-peritoneally at a dose of 50 mg Kg-1 30 or 90 min after carrageenan injection. Then, fluvoxamine was given intra-cerebroventricularly (25, 50 and 100 μg/rat) and intra-thecally (25, 50 and 100 μg/rat) 30 min before the carrageenan challenge. Finally, the effect of mifepristone (5 mg Kg-1), an antagonist of the glucocorticoid receptor, on the anti-edema effect of fluvoxamine (50 mg Kg-1) was investigated. Results showed that intra-peritoneal (IP) administration of fluvoxamine before or after carrageenan injection considerably inhibited paw edema response at 4 h post-carrageenan (p < 0.001), but intra-cerebroventricular (i.c.v.) and intra-thecal (i.t.) injection of fluvoxamine did not alter the degree of paw swelling. The inhibitory effect of fluvoxamine was reduced by the pretreatment of mifepristone (p < 0.01). | en |
| DOI | https://doi.org/10.22037/ijpr.2011.952 | en |
| Keyword | Carrageenan | en |
| Keyword | Fluvoxamine | en |
| Keyword | Intra-cerebroventricular | en |
| Keyword | Intra-thecal | en |
| Keyword | Mifepristone | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Effect of Fluvoxamine on Carrageenan-Induced Paw Edema in Rats Evaluation of the Action Sites | en |
| Type | Original Article | en |
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