The Effect of Vitamin D Consumption During Pregnancy on Maternal Thyroid Function and Depression: A Randomized, Placebo-Controlled, Clinical Trial
| Author | Mohammad Hossein Dabbaghmanesh | en |
| Author | Farideh Vaziri | en |
| Author | Fatemeh Najib | en |
| Author | Samira Nasiri | en |
| Author | Saeedeh Pourahmad | en |
| Orcid | Mohammad Hossein Dabbaghmanesh [0000-0002-4877-0376] | en |
| Orcid | Fatemeh Najib [0000-0003-3396-145X] | en |
| Issued Date | 2019-01-12 | en |
| Abstract | Background: Beyond the vital function of vitamin D in the homeostasis of calcium balance, possible widespread effects of vitamin D are shown in numerous studies. Objectives: The current study aimed at evaluating the effects of vitamin D supplement on thyroid function and postnatal depression. Methods: In the current randomized experimental study, the vitamin D group presented with two 1000 IU vitamin D3 pills (2000 IU) daily from 26th to 28th week of gestation until birth; however, the control group received placebo. Inter- and intra-group comparisons were performed in terms of maternal serum level of 25-hydroxyvitamin D, thyroid-stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase (TPO), and 4th week postnatal depression score. Results: At birth, changes in maternal serum level of 25-hydroxyvitamin D was significantly different between the two groups (P = 0.004). The two study groups were not different significantly in terms of TSH, FT4, and TPO levels at birth (P > 0.05). While, at 4th week postnatal, depression score was significantly different between the two groups (P = 0.002). Conclusions: Vitamin D, 2000 IU /day in late pregnancy could induce a significant difference in the 4th week postnatal depression score independent of thyroid function. | en |
| DOI | https://doi.org/10.5812/jjnpp.65328 | en |
| Keyword | Thyroid Function | en |
| Keyword | Postnatal Depression | en |
| Keyword | Vitamin D | en |
| Keyword | 25-Hydroxyvitamin D3 | en |
| Publisher | Brieflands | en |
| Title | The Effect of Vitamin D Consumption During Pregnancy on Maternal Thyroid Function and Depression: A Randomized, Placebo-Controlled, Clinical Trial | en |
| Type | Brief Report | en |
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