Effects of Aqueous Extract of <i>Berberis integerrima</i> Root on Some Physiological Parameters in Streptozotocin-Induced Diabetic Rats
| Author | Hossein Ashraf | en |
| Author | Reza Heidari | en |
| Author | Vahid Nejati | en |
| Author | Minoo Ilkhanipoor | en |
| Issued Date | 2013-04-30 | en |
| Abstract | Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. Berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of Berberis integerrima root (AEBI) on some physiological parameters in normal and streptozotocin-induced (STZ-induced) diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides (TG), total cholesterol (TC), low density lipoprotein LDL-cholesterol (LDL-C), creatinine (Cr), urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin while body weight, high density lipoprotein HDL-cholesterol (HDL-C) and total protein levels were significantly decreased compared to normal rats. Treatment of diabetic rats with different doses of aqueous extract of Berberis integerrima root (250 and 500 mg/Kg bw) resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL-cholesterol, ALT, AST, ALP, total bilirubin, creatinine and urea while HDL-cholesterol and total protein levels were markedly increased after six weeks compared to untreated diabetic rats. The effects of the AEBI at dose of 500 mg/Kg in all parameters except blood glucose (similar) is more than to the standard drug, glibenclamide (0.6 mg/Kg, p.o.). The results of this study indicate that the tested aqueous extract of Berberis integerrima root possesses hypoglycemic, hypolipidemic and antioxidant effects in STZ-induced diabetic rats. | en |
| DOI | https://doi.org/10.22037/ijpr.2013.1300 | en |
| Keyword | Berberis Integerrima | en |
| Keyword | Streptozotocin | en |
| Keyword | Hypoglycemic | en |
| Keyword | Hypolipidemic | en |
| Keyword | Antioxidant | en |
| Publisher | Brieflands | en |
| Title | Effects of Aqueous Extract of <i>Berberis integerrima</i> Root on Some Physiological Parameters in Streptozotocin-Induced Diabetic Rats | en |
| Type | Original Article | en |
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