Flavonol Glycosides from <i>Euphorbia microsciadia</i> Bioss. with their Immunomodulatory Activities
| Author | Syed Mustafa Ghanadian | en |
| Author | Abdul Majid Ayatollahi | en |
| Author | Suleiman Afsharypour | en |
| Author | Sumaira Hareem | en |
| Author | Omer Mohamed Abdalla | en |
| Author | Jean Jules Kezetas Bankeu | en |
| Issued Date | 2012-07-31 | en |
| Abstract | Four known flavonoids: quercetin 3-O-β-D-rutinoside (Q3Rut), myricetin 3-O-β-D-galactopyranoside (M3Gal), quercetin 3-O-β-D-galactopyranoside (Q3Gal) and quercetin 3-O-β-D-glucopyranoside (Q3Glc), for the first time were isolated from aerial parts of Euphorbia microsciadia. The chemical structure of them was elucidated on the basis of 1 and 2 D-NMR spectra and different spectroscopic techniques. The immunomodulatory activities of isolated compounds were compared using standard T-cell proliferation assay. These data showed that lymphocyte suppression activity of flavonoids (1-4) were comparatively lower than prednisolon as a standard drug. Immunosuppressive activity of flavonoids with hydroxyl groups at both 3′-and 4′-positions in their B-ring (Q3Gal) were more than those with 3′-,4′-and 5′-hydroxyl substitution (M3Gal). In these compounds, Q3Gal showed the most inhibitory activity, whereas M3Gal showed the least lymphocyte antiprolifeartive activity. | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1183 | en |
| Keyword | <i>Euphorbia microsciadia</i> | en |
| Keyword | Flavonoids | en |
| Keyword | Immunomodulatory activity | en |
| Keyword | Flavonol glycosides | en |
| Publisher | Brieflands | en |
| Title | Flavonol Glycosides from <i>Euphorbia microsciadia</i> Bioss. with their Immunomodulatory Activities | en |
| Type | Original Article | en |
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