Synthesis and Biological Evaluation of New Nitroimidazole Derivatives as Anti-<i>Helicobacter pylori</i> Agents Against Metronidazole-Resistant Strains
| Author | Zahra Bayati | en |
| Author | Salimeh Amidi | en |
| Author | Mahnaz Shahabimehr | en |
| Author | Masoud Alebouyeh | en |
| Author | Arash Mahboubi | en |
| Author | Sayyed Abbas Tabatabai | en |
| Orcid | Salimeh Amidi [0000-0002-6032-3237] | en |
| Orcid | Masoud Alebouyeh [0000-0001-7474-2515] | en |
| Orcid | Arash Mahboubi [0000-0002-5140-8159] | en |
| Orcid | Sayyed Abbas Tabatabai [0000-0002-7363-3517] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Since several Helicobacter pylori strains have become resistant to metronidazole, new nitroimidazole derivatives based on metronidazole were designed and synthesized with different substituents on imidazole nitrogen. The activity of the synthesized compounds was evaluated against 20 clinically isolated metronidazole-resistant H. pylori strains. Some synthesized compounds were effective against those metronidazole-resistant H. pylori strains. Three compounds exhibited the most potent inhibitory activities (MIC50 = 8 µg/mL and MIC90 = 16 µg/mL). | en |
| DOI | https://doi.org/10.5812/ijpr-137969 | en |
| Keyword | Nitroimidazole Derivatives | en |
| Keyword | Metronidazole Resistance | en |
| Keyword | <i>Helicobacter pylori</i> | en |
| Keyword | Synthesis | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Biological Evaluation of New Nitroimidazole Derivatives as Anti-<i>Helicobacter pylori</i> Agents Against Metronidazole-Resistant Strains | en |
| Type | Research Article | en |
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