Antiapoptotic Effects of Continuous Training and Selenium Consumption on the Liver Tissue of Cadmium-Exposed Rats
| Author | Hossein Humayun Fard | en |
| Author | Seyed Ali Hosseini | en |
| Author | Mohammad Ali Azarbayjani | en |
| Author | Masoud Nikbakht | en |
| Orcid | Seyed Ali Hosseini [0000-0001-9122-3952] | en |
| Orcid | Mohammad Ali Azarbayjani [0000-0002-3502-7487] | en |
| Issued Date | 2019-07-31 | en |
| Abstract | Background: Cadmium has negative effects on various tissues of the body while selenium has antioxidant activities. Moreover, the benefits of exercise training for apoptotic factors including caspase-3 and cytochrome c, as well as cyclin D, have been regarded. Objectives: Therefore, the present study aimed to evaluate the anti-apoptotic effects of continuous training and selenium consumption on the liver tissue of cadmium-exposed rats. Methods: In this study, 25 rats were selected and randomly divided into five groups of five rats including: (1) control, (2) selenium consumption, (3) continuous training, (4) continuous training with selenium consumption, and (5) sham. For eight weeks, groups 1 to 4 received peritoneal cadmium (2 mg/kg) daily; groups 2 and 4 received peritoneal selenium (0.23 mg/kg) daily; and groups 3 and 4 performed continuous training three sessions per week. Caspase-3, cytochrome c, and cyclin D were measured at the protein level. Results: Cadmium consumption significantly increased the protein levels of caspase-3 and cytochrome c and decreased cyclin D in rats (P = 0.001). Selenium consumption and continuous training significantly decreased the protein levels of caspase-3 and cytochrome c and increased cyclin D in rats exposed to cadmium (P = 0.001). Continuous training along with selenium consumption had interactive effects on increasing the protein levels of cyclin D in rats exposed to cadmium (P = 0.02). Conclusions: It appears that continuous training and selenium consumption have interactive anti-apoptotic effects in the liver tissue of cadmium-exposed rats. | en |
| DOI | https://doi.org/10.5812/mejrh.91278 | en |
| Keyword | Liver | en |
| Keyword | Apoptosis | en |
| Keyword | Continues Training | en |
| Keyword | Selenium | en |
| Keyword | Cadmium | en |
| Publisher | Brieflands | en |
| Title | Antiapoptotic Effects of Continuous Training and Selenium Consumption on the Liver Tissue of Cadmium-Exposed Rats | en |
| Type | Research Article | en |
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