Lower Serum Kindlin-2 Levels Are Associated with Liver Cirrhosis: A Preliminary Study
| Author | Özgür Altun | en |
| Author | Olga Metin | en |
| Author | Yucel Arman | en |
| Author | Şengul Aydın Yoldemir | en |
| Author | Okan Dikker | en |
| Author | Tufan Tukek | en |
| Orcid | Özgür Altun [0000-0003-1810-7490] | en |
| Orcid | Olga Metin [0000-0003-4673-5099] | en |
| Orcid | Yucel Arman [0000-0002-9584-6644] | en |
| Orcid | Şengul Aydın Yoldemir [0000-0003-4236-1181] | en |
| Orcid | Okan Dikker [0000-0002-9153-6139] | en |
| Orcid | Tufan Tukek [0000-0002-4237-1163] | en |
| Accessioned Date | 2026-10-27T09:19:57Z | |
| Issued Date | 2026-12-31 | en |
| Abstract | Background: Kindlin-2 is a focal adhesion protein involved in cell-cell and cell-extracellular matrix adhesion. These functions influence cell behavior and processes such as fibrosis. Kindlin-2 has recently been reported to play important roles in fibrotic diseases. Objectives: This study aimed to assess the association between serum kindlin-2 levels and liver cirrhosis. Methods: The study included 48 individuals with liver cirrhosis and 40 healthy controls. Serum kindlin-2 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Complete blood count parameters and liver function tests were assessed. Liver fibrosis was evaluated using noninvasive indices, including the aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4) index. Mortality risk was evaluated using the Model for End-Stage Liver Disease-Sodium (MELD-Na) score. Results: Serum kindlin-2 levels were lower in the liver cirrhosis group (P = 0.014). Kindlin-2 levels were inversely associated with alanine aminotransferase (ALT), aspartate aminotransferase (AST), and aminotransferase-to-platelet ratio index (APRI) scores and positively associated with platelet count. Low kindlin-2 levels were independently associated with liver cirrhosis. Conclusions: Low serum kindlin-2 levels were associated with liver cirrhosis. Correlations were observed between kindlin-2 levels and markers of liver fibrosis, as well as certain liver function tests. These findings may be a consequence of the cirrhosis process. | en |
| DOI | https://doi.org/10.5812/hepatmon-173193 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/173193 | en |
| Keyword | Kindlin-2 | en |
| Keyword | Liver Fibrosis | en |
| Keyword | Chronic Liver Diseases | en |
| Publisher | Brieflands | en |
| Title | Lower Serum Kindlin-2 Levels Are Associated with Liver Cirrhosis: A Preliminary Study | en |
| Type | Research Article | en |
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