Efficacy of Lamivudine Therapy on Decompensated Liver Cirrhosis Due to Chronic Hepatitis B
| Author | Mahmood Yousefi Mashhour | en |
| Author | Fariborz Mansour Ghanaei | en |
| Author | Hosein Foroutan | en |
| Author | Hadi Ghofrani | en |
| Author | Zahra Purrasuli | en |
| Author | Farahnaz Joukar | en |
| Issued Date | 2007-06-30 | en |
| Abstract | Background and Aims: The aim of this study was to determine the effect of lamivudine on liver function and clinical status of the patients with decompensated cirrhosis arising from hepatitis B virus (HBV).Methods: In a clinical trial on the basis of liver consideration in 55 patients with cirrhosis that had positive HBsAg and HBV DNA, Child-Pugh score more than 8 and some other criteria were treated with lamivudine. In these patients, serumlevel of bilirubin, albumin, ALT, AST and also the PT-INR were controlled at the beginning of study and then at intervals of 2 to 6 months and finally 12 months after the start of treatment.Results: Five patients died in the first 6 months of treatments. The following results are related to 50 patients being under treatment with lamivudine at least for a period of 6 months. In these patients mean Child-Pugh score was decreased from 11 ± 2 to 7 ± 1 (P < 0.0001). All of the patients tolerated this drug very well.Conclusions: Lamivudine can be effective in improvement of liver function in patients with decompensated liver cirrhosis resulting from HBV, but for determination of proper period of treatment, further studies are necessary. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/hepatmon/articles/70031 | en |
| Keyword | Lamivudine | en |
| Keyword | Hepatitis B | en |
| Keyword | Hepatitis C | en |
| Keyword | Cirrhosis | en |
| Publisher | Brieflands | en |
| Title | Efficacy of Lamivudine Therapy on Decompensated Liver Cirrhosis Due to Chronic Hepatitis B | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 70031-pdf.pdf
- Size:
- 385.57 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF