Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients
| Author | Reza Ghanbari | en |
| Author | Mehrdad Ravanshad | en |
| Author | Seyed Younes Hosseini | en |
| Author | Ramin Yaghobi | en |
| Author | Kiana Shahzamani | en |
| Orcid | Mehrdad Ravanshad [0000-0003-1808-2481] | en |
| Issued Date | 2010-06-30 | en |
| Abstract | Background and Aims: Hepatitis G virus/GB virus-C (HGV/GBV-C) is a newly identified member of the Flaviviridae family. Its clinical significance in chronic hepatitis C infection remains controversial. There is a geographical difference in the distribution of GBV-C in the world. The frequency of GBV-C infection among hepatitis C virus (HCV) infected patients varies. The aim of the current study was to determine the prevalence and genotypes of GBV-C among Iranian patients infected with chronic HCV. Methods: Infection with GBV-C was surveyed in 71 chronic confirmed hepatitis C infected patients. These samples were collected at the Digestive Disease Research Center (DDRC) of Shariati Hospital, Tehran, Iran from January to October 2007. The 5’-UTR region of GBV-C RNA was detected using a novel in-house touchdown nested reverse transcription polymerase chain reaction (RT-PCR), the products were sequenced and the results were aligned and phylogenically analyzed. Results: Of the 71 HCV-infected patients, 31 (43.6%) were found positive for GBV-C RNA. Sequencing and phylogenic analysis showed that the samples were Genotype 2 of GBV-C. Conclusions: It seems that there is a high rate of GBV-C infection among Iranian patients infected with chronic HCV. In comparison with the six reference genotypes, it was observed that all the samples were categorized in Genotype 2 of GBV-C, prevalent in North America, Africa and in European countries. Keywords: GBV-C, HCV, Prevalence, Genotyping, Iranian, 5’-UTR | en |
| DOI | https://doi.org/ | en |
| Keyword | GBV-C | en |
| Keyword | HCV | en |
| Keyword | Prevalence | en |
| Keyword | Genotyping | en |
| Keyword | Iranian | en |
| Keyword | 5-UTR | en |
| Publisher | Brieflands | en |
| Title | Genotyping and Infection Rate of GBV-C among Iranian HCV- Infected Patients | en |
| Type | Research Article | en |
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