Effects of Pravastatin in Adriamycin-Induced Nephropathy in Rats
| Author | Esrafil Mansouri | en |
| Author | Mohammad-Ali Assarehzadegan | en |
| Author | Fereshteh Nejad-Dehbashi | en |
| Author | Wesam Kooti | en |
| Issued Date | 2018-10-31 | en |
| Abstract | The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 after ADR injection, the animals were sacrificed. The results showed that administration of pravastatin decreased the levels of 24-h urinary protein (24-h UP), blood urea nitrogen (BUN), and creatinine (p < 0.05) which had increased after the injection of ADR; in addition, pravastatin reversed structural changes seen in ADR group. Furthermore, pravastatin elevated mRNA and protein expression of nephrin (p < 0.05) which had been reduced in ADR group. We conclude that pravastatin protects and treats renal injury induced by ADR. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2290 | en |
| Keyword | Nephropathy | en |
| Keyword | Adriamycin | en |
| Keyword | Pravastatin | en |
| Keyword | Nephroprotective | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Effects of Pravastatin in Adriamycin-Induced Nephropathy in Rats | en |
| Type | Original Article | en |
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