Synthesis and Characterization of a Novel Zinc-Based Metal-Organic Framework Containing Benzoic Acid: A Low-Toxicity Carrier for Drug Delivery
| Author | Xiaomei Ye | en |
| Author | Mengmeng Xiong | en |
| Author | Kangrui Yuan | en |
| Author | Wei Liu | en |
| Author | Xiaoqun Cai | en |
| Author | Yu Yuan | en |
| Author | Yanghang Yuan | en |
| Author | Youfa Qin | en |
| Author | Dudu Wu | en |
| Issued Date | 2023-12-31 | en |
| Abstract | In recent years, metal-organic frameworks (MOFs) have gained attention in the biomedical field, particularly as drug carriers for treating tumors. Therefore, we decided to synthesize a novel benzoic acid Zn-based MOF and study the Zn-based MOFs' drug-delivery properties and the drug-delivery system's anticancer effects. This study successfully synthesized a zinc-based MOF using solvent thermal synthesis. The crystal structure of a Zn-based MOF was investigated using thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. Subsequently, the results of UV spectrophotometry showed that Doxorubicin was successfully loaded with a loading amount of 33.74%. Furthermore, the drug release experiments demonstrated that the Zn-based MOF was pH-sensitive, releasing more at a pH of 3.8 than at pH 5.8 or 7.4. Finally, the Zn-based MOF loaded with drugs exhibited high antitumor activity against HepG2 cells while demonstrating remarkably low toxicity to normal cells (LO2). Taken together, these results demonstrate that the Zn-based MOF has the potential to serve as a carrier in the field of drug delivery systems. | en |
| DOI | https://doi.org/10.5812/ijpr-136238 | en |
| Keyword | Keywords: Metal-Organic Frameworks | en |
| Keyword | Drug Delivery Systems | en |
| Keyword | Benzoic Acid | en |
| Keyword | Doxorubicin | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Characterization of a Novel Zinc-Based Metal-Organic Framework Containing Benzoic Acid: A Low-Toxicity Carrier for Drug Delivery | en |
| Type | Research Article | en |