The Effect of Vitamin D Deficiency Treatment on Hemoglobin Levels in Hemodialysis Patients: A Double-blind, Randomized Controlled Trial
| Author | Seyede Fatemeh Ghasemian | en |
| Author | Shahla Ahmadi Halili | en |
| Author | Fatemeh Hayati | en |
| Author | Seyed Seifollah Beladi-Mousavi | en |
| Author | Shokouh Shayanpour | en |
| Author | Leila Sabetnia | en |
| Orcid | Seyede Fatemeh Ghasemian [0000-0001-5421-6382] | en |
| Orcid | Shahla Ahmadi Halili [0000-0002-5707-3556] | en |
| Orcid | Fatemeh Hayati [0000-0002-2113-2737] | en |
| Orcid | Seyed Seifollah Beladi-Mousavi [0000-0001-6202-3097] | en |
| Orcid | Shokouh Shayanpour [0000-0003-0499-1465] | en |
| Orcid | Leila Sabetnia [0000-0003-0380-4584] | en |
| Issued Date | 2022-07-31 | en |
| Abstract | Background: The role of vitamin D deficiency and hemoglobin levels in renal anemia is well established. However, few studies with inconsistent findings have examined the relationship between vitamin D supplementation and the prevalence and severity of anemia in the chronic kidney disease. Objectives: The present study aimed to evaluate the effect of vitamin D deficiency treatment on hemoglobin levels in hemodialysis patients. Methods: The present study was a double-blind, randomized controlled trial on 60 hemodialysis patients aged 18 - 83 years, who were undergoing maintenance dialysis and receiving erythropoietin. All patients with vitamin D (< 30 ng/mL) referred to the dialysis wards of Imam Khomeini, Razi, and Sina hospitals in Ahvaz in 2019, were assigned into two groups. One group was treated with 500 mg oral calcium-D tablets three times a day, and another group was treated with 50,000 units of D-Pearls weekly. The two groups were treated for 12 weeks. Then they were re-evaluated in terms of response to treatment and the rate of improvement in hemoglobin levels and erythropoietin dose. Results: In each intervention group, vitamin D levels increased significantly (P < 0.001). D-Pearls improved vitamin D deficiency; however, the difference was not statistically significant. This study also showed a significant increase in hemoglobin (> 1 unit) in the calcium-D group; however, such a change was not observed in the D-Pearls group (P = 0.3824). Moreover, there was no difference between the two groups in terms of erythropoietin dose (P = 0.98), blood calcium level (P = 0.57), parathyroid level (P = 0.20), and phosphorus (P = 0.99). Conclusions: Despite its significant limitations,this study revealed vitamin D supplements improved vitamin D deficincy, and calcium-D tablets could improve hemoglobin levels in patient. | en |
| DOI | https://doi.org/10.5812/jjcdc-119008 | en |
| Keyword | Vitamin D Deficiency | en |
| Keyword | Hemoglobin, Hemodialysis | en |
| Keyword | Erythropoietin | en |
| Keyword | End-stage Renal Disease | en |
| Publisher | Brieflands | en |
| Title | The Effect of Vitamin D Deficiency Treatment on Hemoglobin Levels in Hemodialysis Patients: A Double-blind, Randomized Controlled Trial | en |
| Type | Research Article | en |
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