Diagnostic Accuracy of Fine Needle Aspiration for Solitary and Multiple Thyroid Nodules in a Tertiary Care Center
| Author | Fariba Karimi | en |
| Orcid | Fariba Karimi [0000-0002-6107-4826] | en |
| Issued Date | 2017-11-30 | en |
| Abstract | Background: Thyroid nodules are common in clinical practice. They are usually benign, but malignancy must be ruled out. Fine needle aspiration (FNA) biopsy of the thyroid is a rapid and cost-effective procedure in the initial evaluation of a thyroid nodule, but its results may be inaccurate in 10% to 30% of cases. This prospective observational study was conducted to determine the prevalence of thyroid cancer, its related findings, and the diagnostic accuracy of preoperative FNA in a tertiary care center. Methods: We prospectively studied the medical records of 345 subjects, who underwent thyroid resection in the university hospital setting over a 4-year period. Age, gender, FNA and pathologic reports, and whether the lesion was multinodular or a solitary nodule were determined. Results: The sensitivity and specificity of FNA were 64.96% and 62.76%, respectively. The positive predictive value of the test for the diagnosis of malignant nodules was 59.30% and its negative predictive value was 68.20%. In 63.5% of the patients, the preoperative FNA matched the surgical histopathology results. The presence of multinodular goiter was an important risk factor for thyroid malignancy. Fifty-two subjects had papillary microcarcinoma and the rate of aggressive behavior was considerable in this group. Conclusions: Although fine needle aspiration biopsy is the most important step in the workup of the thyroid nodules, it may miss a significant number of malignant lesions. Therefore, there is a mandatory need to evolve other clinical and laboratory adjuncts, which assists the clinicians with the interpretation of FNA more accurately. | en |
| DOI | https://doi.org/10.5812/ijcm.10589 | en |
| URI | https://brieflands.com/journals/ijcm/articles/10589 | en |
| Keyword | Thyroid Nodule | en |
| Keyword | Fine Needle Aspiration | en |
| Keyword | Multinodular Goiter | en |
| Keyword | Papillary Microcarcinoma | en |
| Keyword | Positive Predictive Value | en |
| Keyword | Negative Predictive Value | en |
| Publisher | Brieflands | en |
| Title | Diagnostic Accuracy of Fine Needle Aspiration for Solitary and Multiple Thyroid Nodules in a Tertiary Care Center | en |
| Type | Research Article | en |
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