COVID-19 as an Aggravator of Cardiovascular Diseases: Increasing Immunoglobulin G, a Valuable Prognostic Factor for Heart Failure
| Author | Ali Tahan | en |
| Author | Najmaldin Saki | en |
| Author | Shirin Azizidoost | en |
| Author | Farid Yousefi | en |
| Author | Habib Haybar | en |
| Orcid | Shirin Azizidoost [0000-0002-6121-2176] | en |
| Issued Date | 2023-08-31 | en |
| Abstract | Background: COVID-19 might worsen preexisting cardiac conditions and cause new heart failure (HF). To appropriately triage and treat patients, an early diagnosis is necessary. Objectives: This study assessed the levels of antibodies immunoglobulin G (IgG) and immunoglobulin M (IgM) required for the coronavirus spike S protein in the serum of individuals with cardiovascular disease (CVD) who developed HF complications from COVID-19. Methods: A total of 104 hospitalized patients with confirmed COVID-19 were equally divided into severe COVID-19 cases with new HF evidence and controls. The levels of IgG and IgM antibodies vs SARS-CoV-2 were measured. The possible correlation of antibody levels with underlying cardiac risk factors was also investigated. Results: It was found that 86% of HF patients and 5% of controls had an IgG level greater than 100 AU/mL (P < 0.05). Ischemic heart disease (IHD) was the most common disease in the patient group, and the highest level of antibodies was also found in this group. Conclusions: Increasing IgG during COVID-19 can be one of the signs of worsening heart disease, which is more prevalent in patients with an underlying IHD and hypertension. | en |
| DOI | https://doi.org/10.5812/jjm-139233 | en |
| Keyword | COVID-19 | en |
| Keyword | Heart Failure | en |
| Keyword | Immunoglobulin G | en |
| Keyword | Immunoglobulin M | en |
| Keyword | Risk Factors | en |
| Publisher | Brieflands | en |
| Title | COVID-19 as an Aggravator of Cardiovascular Diseases: Increasing Immunoglobulin G, a Valuable Prognostic Factor for Heart Failure | en |
| Type | Research Article | en |
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