<i>DAT1</i> Gene Polymorphism in Children with Attention Deficit Hyperactivity Disorder
| Author | Seyed - Mahmoud Tabatabaei | en |
| Author | Shahrokh Amiri | en |
| Author | Nasrin Forghani | en |
| Author | Seyed - Gholamreza Noorazar | en |
| Author | Shahin Abdollahi - Fakhim | en |
| Author | Habibeh Barzegar | en |
| Author | Mir - Mahmoud Mirnasab | en |
| Orcid | Shahrokh Amiri [0000-0003-1676-7671] | en |
| Orcid | Habibeh Barzegar [0000-0003-1004-0615] | en |
| Issued Date | 2018-06-30 | en |
| Abstract | Background: Attention deficit hyperactivity disorder (ADHD) as a commonneuro - developmental disorder is associated with inattention, excessive activity, impulsive behavior or a combination of these symptoms. Environmental and genetic factors are involved in this disorder; Dopamine Active Transporter 1 gene (DAT1) is one of these genetic factors. In this study the association between the 10 or 9 - repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3’-untranslated region (UTR) of the DAT1 gene and ADHD, is examined. Methods: A total of 124 children with ADHD and 129 healthy children, ranging from 5 to 14 years old were selected from the north - western area of Iran as the case group and the control group, respectively. DAT1 gene polymorphism was investigated using the PCR-VNTR technique. Results: Using the Hardy - Weinberg law and chi - square test for analyzing the results of the DAT1 gene, it was observed that the genotypes 9/10 and 10/10 of DAT1 gene were significantly higher among children with ADHD than that in control group (P = 0.002). Conclusions: Based on these finding, it can be concluded that a significant relationship exists between DAT1 gene repeats and ADHD in North - west Iran and this can be used as a diagnostic biomarker in the prognosis of this disorder. | en |
| DOI | https://doi.org/10.5812/ijp.13544 | en |
| Keyword | <i>DAT1</i> gene | en |
| Keyword | PCR | en |
| Keyword | Attention Deficit Hyperactivity Disorder (ADHD) | en |
| Keyword | Polymorphism | en |
| Publisher | Brieflands | en |
| Title | <i>DAT1</i> Gene Polymorphism in Children with Attention Deficit Hyperactivity Disorder | en |
| Type | Research Article | en |
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