The Role of Polymorphisms Near the IL28B Gene on Response to Peg-Interferon and Ribavirin in Thalassemic Patients With Hepatitis C
| Author | Bita Behnava | en |
| Author | Heidar Sharafi | en |
| Author | Maryam Keshvari | en |
| Author | Ali Pouryasin | en |
| Author | Leila Mehrnoush | en |
| Author | Shima Salimi | en |
| Author | Pegah Karimi Elizee | en |
| Author | Mehran Ghazimoghaddam | en |
| Author | Seyed Moayed Alavian | en |
| Orcid | Seyed Moayed Alavian [0000-0002-4443-6602] | en |
| Issued Date | 2016-01-01 | en |
| Abstract | Background: Hepatitis C Virus (HCV) is the major cause of liver failure in thalassemic patients. In these patients, iron overload and their comorbidities make difficulties during Pegylated-Interferon (PEG-IFN) and Ribavirin (RBV) therapy. Objectives: We aimed to assess the impact of polymorphisms near the IL28B gene on virological response in HCV - infected thalassemic patients, who were treated with PEG-IFN and RBV. Patients and Methods: This cross - sectional study was conducted on 143 thalassemic patients with chronic hepatitis C, who were treated with a combination of PEG-IFN and RBV regimen. The rs12979860 and rs8099917 polymorphisms were assessed as the most common polymorphisms near the IL28B gene by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The rate of sustained virological response (SVR) was significantly lower in thalassemic patients with HCV genotype-1 infection compared to patients with HCV genotype-3 infection. Among baseline predictors, rs12979860 and rs8099917 polymorphisms were found to be the only parameters associated with achievement of SVR in thalassemic patients with HCV genotype-1 infection however, there was no association between these polymorphisms and the rate of SVR in thalassemic patients with HCV genotype-3 infection. Conclusions: In HCV genotype-1- infected thalassemic patients with rs12979860 CC genotype and without severe comorbidities, PEG-IFN and RBV combination therapy can be tried yet in those with rs12979860 CT/TT it may be reasonable to treat cases with new direct-acting antivirals. | en |
| DOI | https://doi.org/10.5812/hepatmon.32703 | en |
| Keyword | Hepatitis C | en |
| Keyword | Ribavirin | en |
| Keyword | Pegylated-Interferon | en |
| Keyword | Genetic Polymorphism | en |
| Keyword | Thalassemia | en |
| Publisher | Brieflands | en |
| Title | The Role of Polymorphisms Near the IL28B Gene on Response to Peg-Interferon and Ribavirin in Thalassemic Patients With Hepatitis C | en |
| Type | Research Article | en |
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