Synthesis and Evaluation of the Anxiolytic Activity of Some Phthalimide Derivatives in Mice Model of Anxiety
| Author | Farshid Hassanzadeh | en |
| Author | Mohammad Rabbani | en |
| Author | Ghadam Ali Khodarahmi | en |
| Author | Mehrnoosh Moosavi | en |
| Issued Date | 2012-01-31 | en |
| Abstract | The aim of the present study was to synthesis a series of phthalimides based on our previous works and examine their anxiolytic properties. Using a three steps process, phthalimides were prepared from the corresponding di-methyl phthalate derivatives. Phthalic anhydride was nitrated to produce 3-nitrophthalic acid. Ring closer of either 3-nitrophthalic acid or di-methyl phthalate with urea were carried out in reflux condition. Final compounds were prepared by base catalyzed condensation of 4-methylbenzoyl chloride, benzoyl chloride and benzyl chloride with the resulting imides. From the tested compounds, only N-benzoyl 3-nitro-phthalimide was shown to produce anxiolytic activity by increasing the number of entries and time spent in open arms at 10 mg/kg. | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1067 | en |
| Keyword | Phthalimide | en |
| Keyword | 3-Nitrophthalimide | en |
| Keyword | Elevated plus-maze | en |
| Keyword | Anxiety | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Evaluation of the Anxiolytic Activity of Some Phthalimide Derivatives in Mice Model of Anxiety | en |
| Type | Original Article | en |
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