Electroreduction of Tacrolimus as Immunosuppressant agent at Hanging Mercury Drop Electrode: Application to Determination in Pharmaceutical Formulation
| Author | Mohammadbagher Majnooni | en |
| Author | Mohammad B. Gholivand | en |
| Author | Mehdi Khodadadian | en |
| Author | Nazanin-Sadat Afnanzade | en |
| Author | Gholamreza Bahrami | en |
| Issued Date | 2012-06-30 | en |
| Abstract | The adsorptive behavior of the immunosuppressive agent tacrolimus was studied by cyclic and differential-pulse voltammetry on a hanging mercury drop electrode (HMDE). The drug was accumulated at HMDE and two well-defined peak currents were obtained at -1353 and -1417 mV vs. SCE (saturated KCl) in borate buffer (pH 10.0) + 0.1 KCl solution. A voltammetric procedure was developed for the determination of tacrolimus using differential-pulse adsorptive stripping voltammetry (DPAdSV). The optimum working conditions for determination of the drug were established. The analysis of tacrolimus in pharmaceutical dosage forms was carried out satisfactorily. | en |
| DOI | https://doi.org/ | en |
| Keyword | Tacrolimus | en |
| Keyword | Adsorptive stripping | en |
| Keyword | Oltammetry | en |
| Keyword | Immunosuppressant | en |
| Keyword | pharmaceutical | en |
| Keyword | Formulation | en |
| Publisher | Brieflands | en |
| Title | Electroreduction of Tacrolimus as Immunosuppressant agent at Hanging Mercury Drop Electrode: Application to Determination in Pharmaceutical Formulation | en |
| Type | Research Article | en |