Microbial Hydroxylation of 16α, 17α-Epoxyprogesterone by Penicillium Decumbens
| Author | Shuhong Mao | en |
| Author | Xuerong Wang | en |
| Author | Zhijiang Ge | en |
| Author | An Su | en |
| Author | Lixia Zhang | en |
| Author | Yanqing Li | en |
| Author | Xiaoguang Liu | en |
| Author | Fuping Lu | en |
| Issued Date | 2017-07-31 | en |
| Abstract | Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of steroid: 16α, 17α-epoxyprogesterone (1). using Penicilliumdecumbens as biocatalyst was investigated and selective hydroxylation of 1 was observed. The products were separated by silica gel column chromatography, and the structure determination was performed by MS, NMR, and X-ray crystallography. Biotransformation of 1 afforded 7β-hydroxy-16α, 17α-epoxyprogesterone (2). and 7β,11α-dihydroxy-16α,17α- epoxyprogesterone (3). The two novel metabolic products 2 and 3 were reported for the first time. Moreover, the identified C7β- and C11-αhydroxylation is a novel reaction of microbial transformation of steroids by P.decumbens. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2073 | en |
| URI | https://brieflands.com/journals/ijpr/articles/124952 | en |
| Keyword | Steroid | en |
| Keyword | Biotransformation | en |
| Keyword | <i>Penicillium decumbens</i> | en |
| Keyword | 16α | en |
| Keyword | 17α-Epoxyprogesterone | en |
| Keyword | Hydroxylation | en |
| Publisher | Brieflands | en |
| Title | Microbial Hydroxylation of 16α, 17α-Epoxyprogesterone by <i>Penicillium Decumbens</i> | en |
| Type | Research Article | en |
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